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• W1973609893 endingPage "1177" @default.
• W1973609893 startingPage "1172" @default.
• W1973609893 abstract "Alveolar bone destruction is a characteristic feature of periodontal diseases and multinucleated osteoclast cells derived from hemopoietic cells are responsible for bone resorption. Treponema lecithinolyticum is a novel oral spirochete isolated from the periodontal lesions.The effect of whole cell sonicates on the osteoclast differentiation was examined in a co-culture system of hemopoietic mouse bone marrow cells and calvaria derived-osteoblastic cells to clarify the role of T. lecithinolyticum in the alveolar bone destruction associated with periodontal diseases. The differentiated osteoclasts were confirmed by tartrate-resistant acid phosphatase (TRAP) staining.Sonicates of this bacterium stimulated the osteoclast formation in the co-culture system in a dose-dependent manner. The sonicates-induced osteoclast formation was partially inhibited by the heat treatment of sonicates. Indomethacin, which is a prostaglandin inhibitor, decreased the osteoclast formation induced by the bacterial sonicates.These findings suggest that T. lecithinolyticum induces osteoclast differentiation by a prostaglandin E2-dependent mechanism and that heat-labile components may be involved in this process." @default.
• W1973609893 created "2016-06-24" @default.
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• W1973609893 date "2001-09-01" @default.
• W1973609893 modified "2023-10-14" @default.
• W1973609893 title "Effects of Whole Cell Sonicates ofTreponema lecithinolyticumon Osteoclast Differentiation" @default.
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• W1973609893 doi "https://doi.org/10.1902/jop.2000.72.9.1172" @default.
• W1973609893 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11577948" @default.
• W1973609893 hasPublicationYear "2001" @default.
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