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- W1973610432 abstract "d-Fenfluramine is a serotonin (5-hydroxytryptamine, 5-HT) releaser and reuptake inhibitor. It is used to study the neurochemical control of feeding and has been used to treat obesity. It has also been employed as a pharmacological tool to study changes in serotonergic function in psychiatric patients. Brain sites activated by d-fenfluramine via the release of 5-HT have been mapped via the expression of the immediate early gene c-fos. Studies in our laboratory have indicated that d-fenfluramine induces Fos in the hypothalamus and cortex through 5-HT release. The present study investigated whether 5-HT released by d-fenfluramine induces Fos expression in the brain by activating 5-HT1A or 5-HT2A/2C receptors. Rats were pretreated either with WAY-100635, a 5-HT1A antagonist, or ritanserin, a 5-HT2A/2C antagonist, prior to d-fenfluramine injection. Blockade of either 5-HT1A or 5-HT2A/2C receptors was not sufficient to suppress the Fos response to d-fenfluramine in any region of the brain examined, including the cingulate cortex, frontal cortex, caudate–putamen, paraventricular nucleus of the hypothalamus, amygdala, and brainstem. These results indicate that Fos response elicited by d-fenfluramine may be mediated by other receptors, in addition to the 5-HT1A or 5-HT2A/2C receptors." @default.
- W1973610432 created "2016-06-24" @default.
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- W1973610432 date "1998-04-01" @default.
- W1973610432 modified "2023-10-16" @default.
- W1973610432 title "The 5-HT1A and 5-HT2A/2C receptor antagonists WAY-100635 and ritanserin do not attenuate d-fenfluramine-induced Fos expression in the brain" @default.
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- W1973610432 doi "https://doi.org/10.1016/s0006-8993(98)00082-1" @default.
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