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- W1973615445 abstract "Sudden cardiac death (SCD) is a common cause of mortality, with an annual incidence in the United States ranging from 180 000 to 450 000 cases annually.1 Given the frequency and gravity of SCD, there has been considerable effort directed toward decreasing the burden of SCD.2 Most of these efforts have focused on those at highest risk for SCD: (1) patients with heart failure (HF), specifically those with reduced ejection fraction (HFrEF); and (2) patients who have suffered a myocardial infarction and have reduced EF.2 However, although these groups of patients have the highest rate of SCD, the absolute number of SCDs in patients with overt left ventricular (LV) systolic dysfunction pales in comparison with the number of SCDs that occur in the general population.3 Many SCD events in the general population likely occur in asymptomatic individuals who have cardiac structural or functional abnormalities, otherwise known as Stage B (subclinical) HF. For example, previous studies have found that structural heart disease (eg, increased LV mass4) without overt LV systolic dysfunction or HF is associated with increased risk of SCD.Article see p 2095Cardiac remodeling or abnormal myocardial function, which can be associated with electrophysiological dysfunction,5 often predate the development of overt clinical HF. Abnormal electromechanical coupling is likely a common risk factor that predisposes both Stage B (asymptomatic) and Stage C (symptomatic) HF to an increased risk of SCD. For example, hypertension not only leads to LV hypertrophy, but also causes increased myocyte stress, which results in abnormal calcium (Ca 2+ ) handling within the cell and initially gives rise to subtle, subclinical myocardial dysfunction (eg, reduced longitudinal systolic strain), which can only be detected by sensitive imaging modalities (eg, speckle tracking echocardiography6). Ultimately, however, overt cardiac dysfunction occurs and eventually symptomatic HF …" @default.
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- W1973615445 date "2012-10-23" @default.
- W1973615445 modified "2023-09-24" @default.
- W1973615445 title "SERCA2a Gene Therapy for the Prevention of Sudden Cardiac Death" @default.
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- W1973615445 doi "https://doi.org/10.1161/circulationaha.112.138321" @default.
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