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- W1973630175 abstract "The molar solubilization capacities (kappa) and the molar micelle-water partition coefficients (K(M)(N)) in Polysorbate 80 of several drugs (including barbiturates, steroids, and benzoic acid derivatives) are related to their log octanol-water partition coefficients (logP). Both kappa and K(M)(N) values were calculated from solubility versus Polysorbate 80 concentration profiles, which were either experimentally determined or obtained from the literature. There is a linear relationship between logP of the tested compounds and the logarithm of the molar micelle-water partition coefficient (logK(M)(N)). On the other hand molar solubilization capacities are nearly independent of logP. It is shown that the ability of Polysorbate 80 to solubilize a drug can be predicted from its logP value." @default.
- W1973630175 created "2016-06-24" @default.
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- W1973630175 date "2000-05-01" @default.
- W1973630175 modified "2023-09-29" @default.
- W1973630175 title "Relationship between Polysorbate 80 solubilization descriptors and octanol–water partition coefficients of drugs" @default.
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- W1973630175 doi "https://doi.org/10.1016/s0378-5173(00)00386-0" @default.
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