FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1973631031> ?p ?o ?g. }

• W1973631031 endingPage "5225" @default.
• W1973631031 startingPage "5219" @default.
• W1973631031 abstract "Abstract Purpose: Metastatic uveal melanoma is resistant to conventional chemotherapy and immunotherapy. In this study, we investigated the responsiveness of uveal melanoma cell lines to IFNs and the hypomethylating agent decitabine. Experimental Design: The uveal melanoma cell lines 92-1, UW-1, OCM-1, and MKT-BR were exposed to varying concentrations of IFN-α, IFN-γ, and decitabine, alone and in combination. The effects of decitabine on gene expression were examined using DNA microarray analysis. Results: We found that IFN-γ and decitabine induced cell death in uveal melanoma. Whereas a high concentration of IFN-γ (1,000 units/mL) was required to induce cell death, we observed a dose-related increase in cell death when decitabine was used at a range of 0.1 to 10 μmol/L. Strikingly, 1 μmol/L decitabine synergized with 10 to 1,000 units/mL IFN-γ to induce massive cell death. In contrast, decitabine had no effect on three cutaneous melanoma cell lines and exhibited no synergy with either IFN. In uveal melanoma, decitabine up-regulated the expression of genes involved in growth control and apoptosis and down-regulated genes that have been implicated in the malignant phenotype of cutaneous melanoma. The gene up-regulated to the greatest degree by decitabine and whose expression showed a dose-effect across the three concentrations of decitabine was S100A2, a putative tumor suppressor. The genes modulated by decitabine in uveal melanoma were largely unaffected in cutaneous melanoma. Conclusions: These findings form a basis for testing the decitabine/IFN-γ combination in metastatic uveal melanoma and for exploring the role of S100A2 in the susceptibility of uveal melanoma to IFN-mediated cell death." @default.
• W1973631031 created "2016-06-24" @default.
• W1973631031 creator A5034112194 @default.
• W1973631031 creator A5076195918 @default.
• W1973631031 date "2007-09-01" @default.
• W1973631031 modified "2023-09-26" @default.
• W1973631031 title "Decitabine Up-regulates S100A2 Expression and Synergizes with IFN-γ to Kill Uveal Melanoma Cells" @default.
• W1973631031 cites W1533153036 @default.
• W1973631031 cites W1590947486 @default.
• W1973631031 cites W1823669223 @default.
• W1973631031 cites W1974657780 @default.
• W1973631031 cites W1975909997 @default.
• W1973631031 cites W1982635732 @default.
• W1973631031 cites W1991933930 @default.
• W1973631031 cites W1992353552 @default.
• W1973631031 cites W1995168697 @default.
• W1973631031 cites W2017130328 @default.
• W1973631031 cites W2021962948 @default.
• W1973631031 cites W2049920293 @default.
• W1973631031 cites W2053332435 @default.
• W1973631031 cites W2064908261 @default.
• W1973631031 cites W2068697992 @default.
• W1973631031 cites W2081949469 @default.
• W1973631031 cites W2086291465 @default.
• W1973631031 cites W2096217287 @default.
• W1973631031 cites W2100632164 @default.
• W1973631031 cites W2111539417 @default.
• W1973631031 cites W2133463872 @default.
• W1973631031 cites W2140033254 @default.
• W1973631031 cites W2168341294 @default.
• W1973631031 cites W2323327334 @default.
• W1973631031 cites W4256189622 @default.
• W1973631031 doi "https://doi.org/10.1158/1078-0432.ccr-07-0816" @default.
• W1973631031 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17785578" @default.
• W1973631031 hasPublicationYear "2007" @default.
• W1973631031 type Work @default.
• W1973631031 sameAs 1973631031 @default.
• W1973631031 citedByCount "29" @default.
• W1973631031 countsByYear W19736310312013 @default.
• W1973631031 countsByYear W19736310312015 @default.
• W1973631031 countsByYear W19736310312016 @default.
• W1973631031 countsByYear W19736310312017 @default.
• W1973631031 countsByYear W19736310312019 @default.
• W1973631031 countsByYear W19736310312020 @default.
• W1973631031 countsByYear W19736310312021 @default.
• W1973631031 countsByYear W19736310312022 @default.
• W1973631031 crossrefType "journal-article" @default.
• W1973631031 hasAuthorship W1973631031A5034112194 @default.
• W1973631031 hasAuthorship W1973631031A5076195918 @default.
• W1973631031 hasConcept C104317684 @default.
• W1973631031 hasConcept C150194340 @default.
• W1973631031 hasConcept C190283241 @default.
• W1973631031 hasConcept C190727270 @default.
• W1973631031 hasConcept C2776012956 @default.
• W1973631031 hasConcept C2777658100 @default.
• W1973631031 hasConcept C2780235182 @default.
• W1973631031 hasConcept C502942594 @default.
• W1973631031 hasConcept C54355233 @default.
• W1973631031 hasConcept C71924100 @default.
• W1973631031 hasConcept C86803240 @default.
• W1973631031 hasConceptScore W1973631031C104317684 @default.
• W1973631031 hasConceptScore W1973631031C150194340 @default.
• W1973631031 hasConceptScore W1973631031C190283241 @default.
• W1973631031 hasConceptScore W1973631031C190727270 @default.
• W1973631031 hasConceptScore W1973631031C2776012956 @default.
• W1973631031 hasConceptScore W1973631031C2777658100 @default.
• W1973631031 hasConceptScore W1973631031C2780235182 @default.
• W1973631031 hasConceptScore W1973631031C502942594 @default.
• W1973631031 hasConceptScore W1973631031C54355233 @default.
• W1973631031 hasConceptScore W1973631031C71924100 @default.
• W1973631031 hasConceptScore W1973631031C86803240 @default.
• W1973631031 hasIssue "17" @default.
• W1973631031 hasLocation W19736310311 @default.
• W1973631031 hasLocation W19736310312 @default.
• W1973631031 hasOpenAccess W1973631031 @default.
• W1973631031 hasPrimaryLocation W19736310311 @default.
• W1973631031 hasRelatedWork W1973631031 @default.
• W1973631031 hasRelatedWork W1983754555 @default.
• W1973631031 hasRelatedWork W2049473862 @default.
• W1973631031 hasRelatedWork W2054507167 @default.
• W1973631031 hasRelatedWork W2068861579 @default.
• W1973631031 hasRelatedWork W2412245334 @default.
• W1973631031 hasRelatedWork W2515774222 @default.
• W1973631031 hasRelatedWork W2567518952 @default.
• W1973631031 hasRelatedWork W2981372661 @default.
• W1973631031 hasRelatedWork W3203236595 @default.
• W1973631031 hasVolume "13" @default.
• W1973631031 isParatext "false" @default.
• W1973631031 isRetracted "false" @default.
• W1973631031 magId "1973631031" @default.
• W1973631031 workType "article" @default.