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- W1973638771 abstract "Brain activity is associated with changes in optical properties of brain tissue. Optical measurements during brain activation can assess haemoglobin oxygenation, cytochrome-c-oxidase redox state, and two types of changes in light scattering reflecting either membrane potential (fast signal) or cell swelling (slow signal), respectively. In previous studies of exposed brain tissue, optical imaging of brain activity has been achieved at high temporal and microscopical spatial resolution. Now, using near-infrared light that can penetrate biological tissue reasonably well, it has become possible to assess brain activity in human subjects through the intact skull non-invasively. After early studies employing single-site near-infrared spectroscopy, first near-infrared imaging devices are being applied successfully for low-resolution functional brain imaging. Advantages of the optical methods include biochemical specificity, a temporal resolution in the millisecond range, the potential of measuring intracellular and intravascular events simultaneously and the portability of the devices enabling bedside examinations." @default.
- W1973638771 created "2016-06-24" @default.
- W1973638771 creator A5005680629 @default.
- W1973638771 creator A5020270555 @default.
- W1973638771 date "1997-10-01" @default.
- W1973638771 modified "2023-10-09" @default.
- W1973638771 title "Non-invasive optical spectroscopy and imaging of human brain function" @default.
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- W1973638771 doi "https://doi.org/10.1016/s0166-2236(97)01132-6" @default.
- W1973638771 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9347608" @default.
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