Matches in SemOpenAlex for { <https://semopenalex.org/work/W1973640411> ?p ?o ?g. }
- W1973640411 endingPage "356" @default.
- W1973640411 startingPage "347" @default.
- W1973640411 abstract "Choline kinase in mice is encoded by two genes, Chka and Chkb. Disruption of murine Chka leads to embryonic lethality, whereas a spontaneously occurring genomic deletion in murine Chkb results in neonatal bone deformity and hindlimb muscular dystrophy. We have investigated the mechanism by which a lack of choline kinase β, encoded by Chkb, causes hindlimb muscular dystrophy. The biosynthesis of phosphatidylcholine (PC) is impaired in the hindlimbs of Chkb−/− mice, with an accumulation of choline and decreased amount of phosphocholine. The activity of CTP:phosphocholine cytidylyltransferase is also decreased in the hindlimb muscle of mutant mice. Concomitantly, the activities of PC phospholipase C and phospholipase A2 are increased. The mitochondria in Chkb−/− mice are abnormally large and exhibit decreased inner membrane potential. Despite the muscular dystrophy in Chkb−/− mice, we observed increased expression of insulin like growth factor 1 and proliferating cell nuclear antigen. However, regeneration of hindlimb muscles of Chkb−/− mice was impaired when challenged with cardiotoxin. Injection of CDP-choline increased PC content of hindlimb muscle and decreased creatine kinase activity in plasma of Chkb−/− mice. We conclude that the hindlimb muscular dystrophy in Chkb−/− mice is due to attenuated PC biosynthesis and enhanced catabolism of PC." @default.
- W1973640411 created "2016-06-24" @default.
- W1973640411 creator A5026421450 @default.
- W1973640411 creator A5026688325 @default.
- W1973640411 creator A5063084545 @default.
- W1973640411 creator A5073998071 @default.
- W1973640411 date "2009-05-01" @default.
- W1973640411 modified "2023-09-23" @default.
- W1973640411 title "Understanding the muscular dystrophy caused by deletion of choline kinase beta in mice" @default.
- W1973640411 cites W1483078787 @default.
- W1973640411 cites W1601987904 @default.
- W1973640411 cites W1620047152 @default.
- W1973640411 cites W1871997790 @default.
- W1973640411 cites W1973410416 @default.
- W1973640411 cites W1974302922 @default.
- W1973640411 cites W1981261838 @default.
- W1973640411 cites W1992263834 @default.
- W1973640411 cites W1994143431 @default.
- W1973640411 cites W2003696679 @default.
- W1973640411 cites W2003709444 @default.
- W1973640411 cites W2007668490 @default.
- W1973640411 cites W2007815419 @default.
- W1973640411 cites W2011594284 @default.
- W1973640411 cites W2011828000 @default.
- W1973640411 cites W2012965966 @default.
- W1973640411 cites W2020498031 @default.
- W1973640411 cites W2023542615 @default.
- W1973640411 cites W2023972033 @default.
- W1973640411 cites W2028343730 @default.
- W1973640411 cites W2032017606 @default.
- W1973640411 cites W2038939681 @default.
- W1973640411 cites W2039344960 @default.
- W1973640411 cites W2042917569 @default.
- W1973640411 cites W2044318948 @default.
- W1973640411 cites W2044808670 @default.
- W1973640411 cites W2053079324 @default.
- W1973640411 cites W2054368198 @default.
- W1973640411 cites W2055961923 @default.
- W1973640411 cites W2072716779 @default.
- W1973640411 cites W2079826520 @default.
- W1973640411 cites W2083409148 @default.
- W1973640411 cites W2083700023 @default.
- W1973640411 cites W2092772857 @default.
- W1973640411 cites W2098813681 @default.
- W1973640411 cites W2103824419 @default.
- W1973640411 cites W2114596120 @default.
- W1973640411 cites W2128993991 @default.
- W1973640411 cites W2134539889 @default.
- W1973640411 cites W2143213077 @default.
- W1973640411 cites W2144332042 @default.
- W1973640411 cites W2144359625 @default.
- W1973640411 cites W2150856099 @default.
- W1973640411 cites W2152165298 @default.
- W1973640411 cites W2157680277 @default.
- W1973640411 cites W2158254766 @default.
- W1973640411 cites W2163084094 @default.
- W1973640411 cites W2171928223 @default.
- W1973640411 cites W2242114498 @default.
- W1973640411 cites W2289293388 @default.
- W1973640411 cites W2300552860 @default.
- W1973640411 cites W2408914806 @default.
- W1973640411 cites W4239540302 @default.
- W1973640411 cites W4247874496 @default.
- W1973640411 cites W4293247451 @default.
- W1973640411 cites W4294961496 @default.
- W1973640411 doi "https://doi.org/10.1016/j.bbalip.2009.02.006" @default.
- W1973640411 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19236939" @default.
- W1973640411 hasPublicationYear "2009" @default.
- W1973640411 type Work @default.
- W1973640411 sameAs 1973640411 @default.
- W1973640411 citedByCount "40" @default.
- W1973640411 countsByYear W19736404112012 @default.
- W1973640411 countsByYear W19736404112013 @default.
- W1973640411 countsByYear W19736404112014 @default.
- W1973640411 countsByYear W19736404112015 @default.
- W1973640411 countsByYear W19736404112016 @default.
- W1973640411 countsByYear W19736404112017 @default.
- W1973640411 countsByYear W19736404112019 @default.
- W1973640411 countsByYear W19736404112020 @default.
- W1973640411 countsByYear W19736404112021 @default.
- W1973640411 countsByYear W19736404112022 @default.
- W1973640411 countsByYear W19736404112023 @default.
- W1973640411 crossrefType "journal-article" @default.
- W1973640411 hasAuthorship W1973640411A5026421450 @default.
- W1973640411 hasAuthorship W1973640411A5026688325 @default.
- W1973640411 hasAuthorship W1973640411A5063084545 @default.
- W1973640411 hasAuthorship W1973640411A5073998071 @default.
- W1973640411 hasConcept C126322002 @default.
- W1973640411 hasConcept C134018914 @default.
- W1973640411 hasConcept C185592680 @default.
- W1973640411 hasConcept C2776330855 @default.
- W1973640411 hasConcept C2776923060 @default.
- W1973640411 hasConcept C2778918659 @default.
- W1973640411 hasConcept C2779030066 @default.
- W1973640411 hasConcept C2779959927 @default.
- W1973640411 hasConcept C2781123555 @default.
- W1973640411 hasConcept C36880943 @default.
- W1973640411 hasConcept C37113945 @default.