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- W1973643237 abstract "In the present study, we examined the effect of intracerebroventricularly injected choline on plasma ACTH (adrenocorticotrophin) and β-endorphin levels in conscious rats. The intracerebroventricularly injection of choline (50–150 μg) elevated plasma ACTH levels in a dose-dependent manner. Plasma β-endorphin levels were also significantly increased. Pretreatment of rats with mecamylamine (50 μg; intracerebroventricularly), the nicotinic receptor antagonist, completely inhibited the ACTH and β-endorphin response to choline (150 μg; intracerebroventricularly). An antagonist of the muscarinic receptor, atropine (10 μg; intracerebroventricularly), failed to alter these effects. Pretreatment of rats with hemicholinium-3 (20 μg; intracerebroventricularly), a drug which inhibits the uptake of choline into cholinergic neurons, abolished the choline-induced increases in both plasma ACTH and β-endorphin levels. These results indicate that choline can increase plasma concentrations of ACTH and β-endorphin through the activation of central nicotinic acetylcholine receptors." @default.
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- W1973643237 date "1996-08-01" @default.
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- W1973643237 title "Effect of intracerebroventricularly injected choline on plasma ACTH and β-endorphin levels in conscious rats" @default.
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- W1973643237 doi "https://doi.org/10.1016/0014-2999(96)00330-5" @default.
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