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• W1973644872 endingPage "4613" @default.
• W1973644872 startingPage "4609" @default.
• W1973644872 abstract "Insertion sequence IS1 has two coding frames, insA and insB, which are essential for its transposition. Here, we show that a frameshifting event in the -1 direction from the 3' end region of the insA frame to an open reading frame (B' frame), extending from the 5' end of the insB frame, is involved in production of the InsA-B'-InsB fusion protein that has IS1 transposase activity. The frameshifting event is likely to have occurred at the sequence AAAAAC where the insA frame overlaps the B' frame. Interestingly, this sequence is also present in one of the two sequences identified in retroviruses as frameshift signals for production of transframe polyproteins from the overlapping genes gag-pro or gag-pro-pol." @default.
• W1973644872 created "2016-06-24" @default.
• W1973644872 creator A5076785862 @default.
• W1973644872 creator A5091471439 @default.
• W1973644872 date "1989-06-01" @default.
• W1973644872 modified "2023-09-30" @default.
• W1973644872 title "Frameshifting is required for production of the transposase encoded by insertion sequence 1." @default.
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• W1973644872 doi "https://doi.org/10.1073/pnas.86.12.4609" @default.
• W1973644872 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/287320" @default.
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• W1973644872 hasPublicationYear "1989" @default.
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