FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1973649857> ?p ?o ?g. }

• W1973649857 endingPage "230" @default.
• W1973649857 startingPage "222" @default.
• W1973649857 abstract "Ethanol dependence, arising from chronic ethanol exposure, is associated with neuroadaptations of GABAA receptors, evidenced by alterations in various behaviors, receptor responsiveness and subunit gene expression. The present studies explored the effects of ethanol dependence in female rats for comparison with previous studies in our laboratory using male rats. We found that ethanol dependence resulted in differential effects on GABAA receptor gene expression in female rat cerebral cortex compared to ethanol dependent male rats. Notably, chronic ethanol consumption did not change GABAA receptor α1 subunit peptide levels in ethanol dependent female rat cortex, in contrast to previously observed decreases in α1 subunit expression in ethanol dependent male rat cortex. The effects of ethanol dependence on additional GABAA receptor subunit peptide levels (α4, β2/3 and γ2) were similar, but not identical, between female and male rat cortex. When directly compared within the experiment, male and female rats had similar baseline bicuculline seizure thresholds and displayed a similar increase in seizure susceptibility during ethanol withdrawal. Ethanol withdrawn female rats were cross tolerant to the anticonvulsant effects of diazepam, similar to the findings in ethanol withdrawn male rats. Ethanol withdrawn female rats showed a dose-dependent enhancement of the anticonvulsant effect of the neuroactive steroid, THDOC (3α,21-dihydroxy-5α-pregnan-20-one) compared to control animals. This finding is similar to previous observations of increased sensitivity to the anticonvulsant effect of 3α,5α-THP (3α-hydroxy-5α-pregnan-20-one) in ethanol withdrawn male and female rats. In addition, low dose administration of THDOC elevated seizure thresholds in ethanol withdrawn female but not male rats, suggesting that ethanol withdrawn female rats were more responsive to the anticonvulsant effects of this neurosteroid than were ethanol withdrawn male rats. These findings show that gender impacts on adaptations in GABAA receptors elicited by ethanol dependence. However, the physiological outcomes of the differential alterations are not clear. Taken together, these studies suggest that additional mechanisms, beyond effects on GABAA receptor gene expression are involved in the mediation of ethanol dependence and withdrawal." @default.
• W1973649857 created "2016-06-24" @default.
• W1973649857 creator A5024081434 @default.
• W1973649857 creator A5052503226 @default.
• W1973649857 creator A5052608334 @default.
• W1973649857 date "1998-06-01" @default.
• W1973649857 modified "2023-10-13" @default.
• W1973649857 title "Influence of gender on chronic ethanol-induced alterations in GABAA receptors in rats" @default.
• W1973649857 cites W1501604912 @default.
• W1973649857 cites W1575571073 @default.
• W1973649857 cites W1965468598 @default.
• W1973649857 cites W1968427184 @default.
• W1973649857 cites W1968479246 @default.
• W1973649857 cites W1978399465 @default.
• W1973649857 cites W1980844720 @default.
• W1973649857 cites W1983382176 @default.
• W1973649857 cites W1995357866 @default.
• W1973649857 cites W1995894883 @default.
• W1973649857 cites W1998624786 @default.
• W1973649857 cites W2012767314 @default.
• W1973649857 cites W2014742554 @default.
• W1973649857 cites W2018695237 @default.
• W1973649857 cites W2019873672 @default.
• W1973649857 cites W2024344189 @default.
• W1973649857 cites W2053368541 @default.
• W1973649857 cites W2056310348 @default.
• W1973649857 cites W2058404259 @default.
• W1973649857 cites W2058714039 @default.
• W1973649857 cites W2066394439 @default.
• W1973649857 cites W2076787408 @default.
• W1973649857 cites W2077548587 @default.
• W1973649857 cites W2077860191 @default.
• W1973649857 cites W2114888020 @default.
• W1973649857 cites W2124597765 @default.
• W1973649857 cites W2144622136 @default.
• W1973649857 cites W4245117662 @default.
• W1973649857 doi "https://doi.org/10.1016/s0006-8993(98)00357-6" @default.
• W1973649857 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9689472" @default.
• W1973649857 hasPublicationYear "1998" @default.
• W1973649857 type Work @default.
• W1973649857 sameAs 1973649857 @default.
• W1973649857 citedByCount "66" @default.
• W1973649857 countsByYear W19736498572012 @default.
• W1973649857 countsByYear W19736498572014 @default.
• W1973649857 countsByYear W19736498572017 @default.
• W1973649857 countsByYear W19736498572018 @default.
• W1973649857 countsByYear W19736498572019 @default.
• W1973649857 countsByYear W19736498572020 @default.
• W1973649857 countsByYear W19736498572021 @default.
• W1973649857 countsByYear W19736498572023 @default.
• W1973649857 crossrefType "journal-article" @default.
• W1973649857 hasAuthorship W1973649857A5024081434 @default.
• W1973649857 hasAuthorship W1973649857A5052503226 @default.
• W1973649857 hasAuthorship W1973649857A5052608334 @default.
• W1973649857 hasConcept C126322002 @default.
• W1973649857 hasConcept C134018914 @default.
• W1973649857 hasConcept C15744967 @default.
• W1973649857 hasConcept C168258287 @default.
• W1973649857 hasConcept C169760540 @default.
• W1973649857 hasConcept C170493617 @default.
• W1973649857 hasConcept C185592680 @default.
• W1973649857 hasConcept C2775858608 @default.
• W1973649857 hasConcept C2778186239 @default.
• W1973649857 hasConcept C2780161600 @default.
• W1973649857 hasConcept C2780763569 @default.
• W1973649857 hasConcept C44796713 @default.
• W1973649857 hasConcept C55493867 @default.
• W1973649857 hasConcept C71924100 @default.
• W1973649857 hasConceptScore W1973649857C126322002 @default.
• W1973649857 hasConceptScore W1973649857C134018914 @default.
• W1973649857 hasConceptScore W1973649857C15744967 @default.
• W1973649857 hasConceptScore W1973649857C168258287 @default.
• W1973649857 hasConceptScore W1973649857C169760540 @default.
• W1973649857 hasConceptScore W1973649857C170493617 @default.
• W1973649857 hasConceptScore W1973649857C185592680 @default.
• W1973649857 hasConceptScore W1973649857C2775858608 @default.
• W1973649857 hasConceptScore W1973649857C2778186239 @default.
• W1973649857 hasConceptScore W1973649857C2780161600 @default.
• W1973649857 hasConceptScore W1973649857C2780763569 @default.
• W1973649857 hasConceptScore W1973649857C44796713 @default.
• W1973649857 hasConceptScore W1973649857C55493867 @default.
• W1973649857 hasConceptScore W1973649857C71924100 @default.
• W1973649857 hasIssue "1-2" @default.
• W1973649857 hasLocation W19736498571 @default.
• W1973649857 hasLocation W19736498572 @default.
• W1973649857 hasOpenAccess W1973649857 @default.
• W1973649857 hasPrimaryLocation W19736498571 @default.
• W1973649857 hasRelatedWork W1967229232 @default.
• W1973649857 hasRelatedWork W1969942264 @default.
• W1973649857 hasRelatedWork W1973115552 @default.
• W1973649857 hasRelatedWork W1991770912 @default.
• W1973649857 hasRelatedWork W2029394013 @default.
• W1973649857 hasRelatedWork W2053733602 @default.
• W1973649857 hasRelatedWork W2125034616 @default.
• W1973649857 hasRelatedWork W2613968738 @default.
• W1973649857 hasRelatedWork W3200975106 @default.
• W1973649857 hasRelatedWork W4360934225 @default.
• W1973649857 hasVolume "796" @default.

• next