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• W1973662041 abstract "Polyphenols from Hibiscus sabdariffa calices were administered to patients with metabolic syndrome (125 mg/kg/day for 4 wk, n = 31) and spontaneously hypertensive rats (125 or 60 mg/kg in a single dose or daily for 1 wk, n = 8 for each experimental group). The H. sabdariffa extract improved metabolism, displayed potent anti-inflammatory and antioxidant activities, and significantly reduced blood pressure in both humans and rats. Diuresis and inhibition of the angiotensin I-converting enzyme were found to be less important mechanisms than those related to the antioxidant, anti-inflammatory, and endothelium-dependent effects to explain the beneficial actions. Notably, polyphenols induced a favorable endothelial response that should be considered in the management of metabolic cardiovascular risks." @default.
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• W1973662041 date "2014-02-24" @default.
• W1973662041 modified "2023-10-18" @default.
• W1973662041 title "<i>Hibiscus sabdariffa</i> extract lowers blood pressure and improves endothelial function" @default.
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• W1973662041 doi "https://doi.org/10.1002/mnfr.201300774" @default.
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