Matches in SemOpenAlex for { <https://semopenalex.org/work/W1973662076> ?p ?o ?g. }
Showing items 1 to 56 of
56
with 100 items per page.
- W1973662076 abstract "Lovastatin, a competitive inhibitor of the rate limiting enzyme in cholesterol biosynthesis, has been shown to be an effective hypocholesterolaemic agent when given in relatively short term studies to normal human subjects and patients with primary hypercholesterolaemia. The present report reviews the author's experience with lovastatin in the treatment of patients with hypercholesterolaemia (predominantly attributable to heterozygous familial hypercholesterolaemia) over a four year period. Lovastatin has been well tolerated and patients maintained on this drug as a single agent have shown sustained reductions in the plasma concentrations of total and low density lipoprotein cholesterol. The hypocholesterolaemic effects of lovastatin can be potentiated by combination therapy with other currently approved lipid lowering medications including bile acid sequestrants and nicotinic acid. Side effects have been uncommon and no consistent pattern of adverse effects of lovastatin has developed with more prolonged use. Lovastatin and related drugs represent a major advance in the therapy of hypercholesterolaemia." @default.
- W1973662076 created "2016-06-24" @default.
- W1973662076 creator A5009712941 @default.
- W1973662076 date "1987-08-02" @default.
- W1973662076 modified "2023-09-25" @default.
- W1973662076 title "Long term administration of lovastatin in the treatment of hypercholesterolaemia" @default.
- W1973662076 doi "https://doi.org/10.1093/eurheartj/8.suppl_e.103" @default.
- W1973662076 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3678268" @default.
- W1973662076 hasPublicationYear "1987" @default.
- W1973662076 type Work @default.
- W1973662076 sameAs 1973662076 @default.
- W1973662076 citedByCount "16" @default.
- W1973662076 crossrefType "journal-article" @default.
- W1973662076 hasAuthorship W1973662076A5009712941 @default.
- W1973662076 hasConcept C126322002 @default.
- W1973662076 hasConcept C134018914 @default.
- W1973662076 hasConcept C197934379 @default.
- W1973662076 hasConcept C2776694085 @default.
- W1973662076 hasConcept C2776839432 @default.
- W1973662076 hasConcept C2778163477 @default.
- W1973662076 hasConcept C2779399885 @default.
- W1973662076 hasConcept C2780035454 @default.
- W1973662076 hasConcept C2780072125 @default.
- W1973662076 hasConcept C2780940807 @default.
- W1973662076 hasConcept C71924100 @default.
- W1973662076 hasConcept C98274493 @default.
- W1973662076 hasConceptScore W1973662076C126322002 @default.
- W1973662076 hasConceptScore W1973662076C134018914 @default.
- W1973662076 hasConceptScore W1973662076C197934379 @default.
- W1973662076 hasConceptScore W1973662076C2776694085 @default.
- W1973662076 hasConceptScore W1973662076C2776839432 @default.
- W1973662076 hasConceptScore W1973662076C2778163477 @default.
- W1973662076 hasConceptScore W1973662076C2779399885 @default.
- W1973662076 hasConceptScore W1973662076C2780035454 @default.
- W1973662076 hasConceptScore W1973662076C2780072125 @default.
- W1973662076 hasConceptScore W1973662076C2780940807 @default.
- W1973662076 hasConceptScore W1973662076C71924100 @default.
- W1973662076 hasConceptScore W1973662076C98274493 @default.
- W1973662076 hasLocation W19736620761 @default.
- W1973662076 hasLocation W19736620762 @default.
- W1973662076 hasOpenAccess W1973662076 @default.
- W1973662076 hasPrimaryLocation W19736620761 @default.
- W1973662076 hasRelatedWork W1972011552 @default.
- W1973662076 hasRelatedWork W1994838191 @default.
- W1973662076 hasRelatedWork W1999568358 @default.
- W1973662076 hasRelatedWork W2008351015 @default.
- W1973662076 hasRelatedWork W2037627305 @default.
- W1973662076 hasRelatedWork W2091911513 @default.
- W1973662076 hasRelatedWork W2185120011 @default.
- W1973662076 hasRelatedWork W2405641618 @default.
- W1973662076 hasRelatedWork W2479749263 @default.
- W1973662076 hasRelatedWork W4250670026 @default.
- W1973662076 isParatext "false" @default.
- W1973662076 isRetracted "false" @default.
- W1973662076 magId "1973662076" @default.
- W1973662076 workType "article" @default.