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- W1973662826 abstract "reactivity of plasma cell cytoplasm and the amyloid deposits with the same antibody suggests that common epitopes are present in Ax and the precursor light-chain protein. Macrophages have been considered likely cells for involvement with the precursor protein degradation required for amyloid f~rmation.~ Although all of the tumors reported here had few to large numbers of foreign-body-type multinucleated macrophages tightly apposed to amyloid deposits, none of the macrophages reacted with HAR. Therefore, the macrophages in these cases probably were present in response to the amyloid and were not involved in processing the precursor protein. The single feline plasma cell tumor evaluated had similar although less intense reactivity of the amyloid deposits than did the canine neoplasms. The staining was specific and again indicated that the amyloid was of light chain origin. Sequencing of light-chain-origin amyloid deposits has previously been reported in a cat in association with multicentric plasma cell neoplasia.2 Plasma cell tumors with deposition of amyloid are an interesting subset of neoplasms, and the studies reported here confirm the suspected immunoglobulin derivation of these deposits. The Ax antibody HAR appears to have good crossreactivity between species, having identified Ax in formalinfixed, paraffin-embedded tissues from human beings, horses, dogs, and a" @default.
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- W1973662826 date "1994-05-01" @default.
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- W1973662826 title "Spontaneous Thymic Lymphoma in Severe Combined Immunodeficiency (SCID) Mice Engrafted with Human Peripheral Blood Lymphocytes" @default.
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- W1973662826 doi "https://doi.org/10.1177/030098589403100318" @default.
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