FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1973664335> ?p ?o ?g. }

• W1973664335 endingPage "917" @default.
• W1973664335 startingPage "902" @default.
• W1973664335 abstract "Multiple sclerosis is a chronic autoimmune demyelinating disease of the central nervous system, which is thought to be triggered by environmental factors in genetically susceptible individuals leading to activation of autoreactive T lymphocytes. Large multi-centre genome-wide association studies have identified multiple genetic risk loci in multiple sclerosis. In this study, we investigated T cell transcriptomic changes in experimental autoimmune encephalomyelitis, an animal model for multiple sclerosis. We correlated these findings with the multiple sclerosis risk genes postulated by the most recent Immunochip analysis and found that multiple sclerosis susceptibility genes were significantly regulated in experimental autoimmune encephalomyelitis. Our data indicate that nine distinct genes associated with multiple sclerosis risk, Bach2, Il2ra, Irf8, Mertk, Odf3b, Plek, Rgs1, Slc30a7 and Thada, can be confirmed to be differentially regulated in pathogenic CD4(+) T cells. During the effector phase within the inflamed CNS, CD4(+) T cells undergo comprehensive transformation and we identified key transcription factors and signalling networks involved in this process. The transformation was linked to metabolic changes with the involvement of liver X receptor/retinoid X receptor signalling and cholesterol biosynthesis, which might control the T cell effector function in the central nervous system. Thus, our study confirms the involvement of multiple sclerosis risk genes in the pathophysiology of the animal model and sheds light on additional disease-relevant inflammatory networks." @default.
• W1973664335 created "2016-06-24" @default.
• W1973664335 creator A5000458463 @default.
• W1973664335 creator A5002019832 @default.
• W1973664335 creator A5029483794 @default.
• W1973664335 creator A5031286550 @default.
• W1973664335 creator A5034957456 @default.
• W1973664335 creator A5045243818 @default.
• W1973664335 creator A5068489993 @default.
• W1973664335 creator A5083000991 @default.
• W1973664335 creator A5085433800 @default.
• W1973664335 date "2015-02-09" @default.
• W1973664335 modified "2023-10-14" @default.
• W1973664335 title "New candidates for CD4 T cell pathogenicity in experimental neuroinflammation and multiple sclerosis" @default.
• W1973664335 cites W1506310174 @default.
• W1973664335 cites W1597647646 @default.
• W1973664335 cites W1602815942 @default.
• W1973664335 cites W1645795322 @default.
• W1973664335 cites W1832248617 @default.
• W1973664335 cites W1912262500 @default.
• W1973664335 cites W1916037019 @default.
• W1973664335 cites W1950448919 @default.
• W1973664335 cites W1970835952 @default.
• W1973664335 cites W1973154630 @default.
• W1973664335 cites W1973872104 @default.
• W1973664335 cites W1975046858 @default.
• W1973664335 cites W1981408859 @default.
• W1973664335 cites W1985201708 @default.
• W1973664335 cites W1993223367 @default.
• W1973664335 cites W1993662841 @default.
• W1973664335 cites W1999745515 @default.
• W1973664335 cites W2002094657 @default.
• W1973664335 cites W2006249161 @default.
• W1973664335 cites W2010734646 @default.
• W1973664335 cites W2011736381 @default.
• W1973664335 cites W2011882192 @default.
• W1973664335 cites W2017893786 @default.
• W1973664335 cites W2020541351 @default.
• W1973664335 cites W2020733241 @default.
• W1973664335 cites W2038044127 @default.
• W1973664335 cites W2040547343 @default.
• W1973664335 cites W2043897997 @default.
• W1973664335 cites W2046612976 @default.
• W1973664335 cites W2052838381 @default.
• W1973664335 cites W2053553562 @default.
• W1973664335 cites W2054827104 @default.
• W1973664335 cites W2055669694 @default.
• W1973664335 cites W2056679356 @default.
• W1973664335 cites W2056835764 @default.
• W1973664335 cites W2057121293 @default.
• W1973664335 cites W2061882872 @default.
• W1973664335 cites W2063253401 @default.
• W1973664335 cites W2072449713 @default.
• W1973664335 cites W2076889715 @default.
• W1973664335 cites W2082970810 @default.
• W1973664335 cites W2084388036 @default.
• W1973664335 cites W2085534739 @default.
• W1973664335 cites W2086171828 @default.
• W1973664335 cites W2091504605 @default.
• W1973664335 cites W2093853003 @default.
• W1973664335 cites W2094354621 @default.
• W1973664335 cites W2095649879 @default.
• W1973664335 cites W2102848212 @default.
• W1973664335 cites W2104016841 @default.
• W1973664335 cites W2107277218 @default.
• W1973664335 cites W2108335498 @default.
• W1973664335 cites W2110228129 @default.
• W1973664335 cites W2110491264 @default.
• W1973664335 cites W2116686907 @default.
• W1973664335 cites W2117427121 @default.
• W1973664335 cites W2119275893 @default.
• W1973664335 cites W2120064570 @default.
• W1973664335 cites W2121395252 @default.
• W1973664335 cites W2121810154 @default.
• W1973664335 cites W2122082443 @default.
• W1973664335 cites W2122084527 @default.
• W1973664335 cites W2122429701 @default.
• W1973664335 cites W2124449323 @default.
• W1973664335 cites W2125987139 @default.
• W1973664335 cites W2128016314 @default.
• W1973664335 cites W2129247811 @default.
• W1973664335 cites W2131107006 @default.
• W1973664335 cites W2135403800 @default.
• W1973664335 cites W2142017607 @default.
• W1973664335 cites W2142832537 @default.
• W1973664335 cites W2145103029 @default.
• W1973664335 cites W2145122687 @default.
• W1973664335 cites W2147519918 @default.
• W1973664335 cites W2151935214 @default.
• W1973664335 cites W2157837362 @default.
• W1973664335 cites W2164272298 @default.
• W1973664335 cites W2165246446 @default.
• W1973664335 cites W2488983277 @default.
• W1973664335 doi "https://doi.org/10.1093/brain/awu408" @default.
• W1973664335 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25665584" @default.
• W1973664335 hasPublicationYear "2015" @default.
• W1973664335 type Work @default.
• W1973664335 sameAs 1973664335 @default.

• next