Matches in SemOpenAlex for { <https://semopenalex.org/work/W1973666710> ?p ?o ?g. }
- W1973666710 endingPage "10" @default.
- W1973666710 startingPage "1" @default.
- W1973666710 abstract "Peyronie’s disease (PD) is characterized with formation of fibrous plaques which result in penile deformity, pain, and erectile dysfunction. The aim of this study was to investigate the activation of the intrinsic apoptotic pathway in plaques from PD patients. Tunica albuginea from either PD or control patients was assessed for the expression of bax, bcl-2 and caspases 9 and 3 using immunohistochemistry and by measurement of apoptotic cells using TUNEL assay. Bax overexpression was observed in metaplastic bone tissue, in fibroblasts, and in myofibroblast of plaques from PD patients. Little or no bcl-2 immunostaining was detected in samples from either patients or controls. Caspase 3 immunostaining was very strong in fibrous tissue, in metaplasic bone osteocytes, and in primary ossification center osteoblasts. Moderate caspase 9 immunostaining was seen in fibrous cells plaques and in osteocytes and osteoblasts of primary ossification centers from PD patients. Control samples were negative for caspase 9 immunostaining. In PD patients the TUNEL immunoassay showed intense immunostaining of fibroblasts and myofibroblasts, the absence of apoptotic cells in metaplasic bone tissue and on the border between fibrous and metaplastic bone tissue. Apoptosis occurs in stabilized PD plaques and is partly induced by the intrinsic pathway." @default.
- W1973666710 created "2016-06-24" @default.
- W1973666710 creator A5004916923 @default.
- W1973666710 creator A5007884869 @default.
- W1973666710 creator A5013077987 @default.
- W1973666710 creator A5017136849 @default.
- W1973666710 creator A5043914535 @default.
- W1973666710 creator A5045209885 @default.
- W1973666710 creator A5054161728 @default.
- W1973666710 creator A5059983020 @default.
- W1973666710 creator A5061835885 @default.
- W1973666710 creator A5067452360 @default.
- W1973666710 creator A5069341528 @default.
- W1973666710 creator A5080996267 @default.
- W1973666710 creator A5089780509 @default.
- W1973666710 date "2014-01-01" @default.
- W1973666710 modified "2023-10-02" @default.
- W1973666710 title "The Role of Intrinsic Pathway in Apoptosis Activation and Progression in Peyronie’s Disease" @default.
- W1973666710 cites W1512598683 @default.
- W1973666710 cites W1536370869 @default.
- W1973666710 cites W1578030232 @default.
- W1973666710 cites W1599376451 @default.
- W1973666710 cites W1602731140 @default.
- W1973666710 cites W1916218535 @default.
- W1973666710 cites W1946147611 @default.
- W1973666710 cites W1975204835 @default.
- W1973666710 cites W1993224545 @default.
- W1973666710 cites W1999580326 @default.
- W1973666710 cites W2000446104 @default.
- W1973666710 cites W2002983554 @default.
- W1973666710 cites W2008296073 @default.
- W1973666710 cites W2009183764 @default.
- W1973666710 cites W2026531128 @default.
- W1973666710 cites W2027249644 @default.
- W1973666710 cites W2033847504 @default.
- W1973666710 cites W2042270638 @default.
- W1973666710 cites W2061384942 @default.
- W1973666710 cites W2080613199 @default.
- W1973666710 cites W2082881543 @default.
- W1973666710 cites W2087759673 @default.
- W1973666710 cites W2089740836 @default.
- W1973666710 cites W2090415578 @default.
- W1973666710 cites W2101752626 @default.
- W1973666710 cites W2103154123 @default.
- W1973666710 cites W2107772938 @default.
- W1973666710 cites W2116025737 @default.
- W1973666710 cites W2124312710 @default.
- W1973666710 cites W2125168329 @default.
- W1973666710 cites W2127227729 @default.
- W1973666710 cites W2132800551 @default.
- W1973666710 cites W2134979684 @default.
- W1973666710 cites W2140390778 @default.
- W1973666710 cites W2141486934 @default.
- W1973666710 cites W2152067194 @default.
- W1973666710 cites W2162623460 @default.
- W1973666710 cites W2166443466 @default.
- W1973666710 cites W2325792835 @default.
- W1973666710 cites W2334785913 @default.
- W1973666710 cites W4230379773 @default.
- W1973666710 cites W4233484287 @default.
- W1973666710 cites W4253606585 @default.
- W1973666710 doi "https://doi.org/10.1155/2014/616149" @default.
- W1973666710 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4147380" @default.
- W1973666710 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25197653" @default.
- W1973666710 hasPublicationYear "2014" @default.
- W1973666710 type Work @default.
- W1973666710 sameAs 1973666710 @default.
- W1973666710 citedByCount "74" @default.
- W1973666710 countsByYear W19736667102015 @default.
- W1973666710 countsByYear W19736667102016 @default.
- W1973666710 countsByYear W19736667102017 @default.
- W1973666710 countsByYear W19736667102018 @default.
- W1973666710 countsByYear W19736667102019 @default.
- W1973666710 countsByYear W19736667102020 @default.
- W1973666710 countsByYear W19736667102021 @default.
- W1973666710 countsByYear W19736667102022 @default.
- W1973666710 countsByYear W19736667102023 @default.
- W1973666710 crossrefType "journal-article" @default.
- W1973666710 hasAuthorship W1973666710A5004916923 @default.
- W1973666710 hasAuthorship W1973666710A5007884869 @default.
- W1973666710 hasAuthorship W1973666710A5013077987 @default.
- W1973666710 hasAuthorship W1973666710A5017136849 @default.
- W1973666710 hasAuthorship W1973666710A5043914535 @default.
- W1973666710 hasAuthorship W1973666710A5045209885 @default.
- W1973666710 hasAuthorship W1973666710A5054161728 @default.
- W1973666710 hasAuthorship W1973666710A5059983020 @default.
- W1973666710 hasAuthorship W1973666710A5061835885 @default.
- W1973666710 hasAuthorship W1973666710A5067452360 @default.
- W1973666710 hasAuthorship W1973666710A5069341528 @default.
- W1973666710 hasAuthorship W1973666710A5080996267 @default.
- W1973666710 hasAuthorship W1973666710A5089780509 @default.
- W1973666710 hasBestOaLocation W19736667101 @default.
- W1973666710 hasConcept C105702510 @default.
- W1973666710 hasConcept C142724271 @default.
- W1973666710 hasConcept C185592680 @default.
- W1973666710 hasConcept C190283241 @default.
- W1973666710 hasConcept C196795494 @default.
- W1973666710 hasConcept C204232928 @default.