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W1973668442 abstract "A new series of 7,8-disubstituted pyrazolobenzodiazepines based on the lead compound 1 have been synthesized and evaluated for their effects on mitosis and angiogenesis. Described herein is the design, synthesis, SAR, and antitumor activity of these compounds leading to the identification of R1530, which was selected for clinical evaluation." @default.
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W1973668442 date "2013-01-22" @default.
W1973668442 modified "2023-10-11" @default.
W1973668442 title "Discovery of a Highly Potent, Orally Active Mitosis/Angiogenesis Inhibitor R1530 for the Treatment of Solid Tumors" @default.
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W1973668442 doi "https://doi.org/10.1021/ml300351e" @default.
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