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- W1973669031 abstract "A variety of endogenous and exogenous factors can influence sex steroid production by salmon ovarian follicles and ultimately impact reproductive development. We examined the effect of an aromatase inhibitor, fadrozole, and common environmental contaminants (PAHs) on sex steroid secretion by ovarian follicles. Ovarian follicles of coho salmon were incubatedin vitrowith various concentrations of testosterone (0.10–0.40 μM) and fadrozole (10 and 100 μM), or with varying doses (between 0.05 and 5.0 μM) of the PAHs β-naphthoflavone (BNF) and 20-methylcholanthrene (20-MC). 17β-Estradiol secretion was significantly reduced when follicles were incubated in the presence of fadrozole, BNF, or 20-MC. In contrast, 17β-estradiol production by ovarian follicles increased in a dose-dependent manner when incubated with increasing doses of the aromatizable androgen testosterone. Although increasing doses of PAHs significantly reduced follicular 17β-estradiol production no effect on testosterone secretion was observed. Hence, both fadrozole and PAHs can significantly reduce 17β-estradiol secretion by salmon ovarian follicles and may affect female sexual development." @default.
- W1973669031 created "2016-06-24" @default.
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- W1973669031 date "1997-05-01" @default.
- W1973669031 modified "2023-10-14" @default.
- W1973669031 title "The Effect of the Aromatase Inhibitor Fadrozole and Two Polynuclear Aromatic Hydrocarbons on Sex Steroid Secretion by Ovarian Follicles of Coho Salmon" @default.
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- W1973669031 doi "https://doi.org/10.1006/gcen.1996.6855" @default.
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