FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1973670690> ?p ?o ?g. }

• W1973670690 endingPage "977" @default.
• W1973670690 startingPage "970" @default.
• W1973670690 abstract "The neuropathology of Huntington’s disease includes nuclear and cytoplasmic inclusions, striatal neuronal loss, and gliosis. Previous work put forward a tantalizing proposal that disruption of axonal transport within long, narrow-caliber axons caused accumulations that could elicit cell death, ultimately resulting in neuronal dysfunction. Although a role for the Huntington’s disease protein huntingtin (HTT) has been reported in axonal transport, it is unclear whether HTT affects the transport of all vesicles or influences only a specific class of vesicles. As an interaction between HTT and Rab5 was previously shown to mediate transport on actin filaments, here we tested the hypothesis that a HTT-Rab5 complex also exists for transport on microtubules during axonal transport. Surprisingly, we found that HTT influences Rab11 vesicles, not Rab5 vesicles. Reduction of HTT perturbed the transport of Rab11 vesicles. Reductions in kinesin and dynein motors also perturbed Rab11 vesicle transport indicating that these motors are required for bidirectional transport of Rab11. These results suggest that HTT plays a key role in the movement of Rab11 vesicles within axons. Thus, disruption of transport mediated by mutant HTT could contribute to early neuropathology observed in Huntington’s diseases." @default.
• W1973670690 created "2016-06-24" @default.
• W1973670690 creator A5022667013 @default.
• W1973670690 creator A5048725628 @default.
• W1973670690 creator A5055522939 @default.
• W1973670690 date "2012-11-14" @default.
• W1973670690 modified "2023-10-18" @default.
• W1973670690 title "In-vivo evidence for the disruption of Rab11 vesicle transport by loss of huntingtin" @default.
• W1973670690 cites W1877780738 @default.
• W1973670690 cites W1982623268 @default.
• W1973670690 cites W1983511812 @default.
• W1973670690 cites W1991311491 @default.
• W1973670690 cites W1991379362 @default.
• W1973670690 cites W1996679985 @default.
• W1973670690 cites W2002644780 @default.
• W1973670690 cites W2016051706 @default.
• W1973670690 cites W2052102093 @default.
• W1973670690 cites W2077904579 @default.
• W1973670690 cites W2080118783 @default.
• W1973670690 cites W2081595285 @default.
• W1973670690 cites W2091323369 @default.
• W1973670690 cites W2099198611 @default.
• W1973670690 cites W2122261008 @default.
• W1973670690 cites W2127465368 @default.
• W1973670690 cites W2130587901 @default.
• W1973670690 cites W2144875895 @default.
• W1973670690 cites W2156928520 @default.
• W1973670690 cites W2159269805 @default.
• W1973670690 cites W2164763690 @default.
• W1973670690 cites W2167721936 @default.
• W1973670690 cites W2168317598 @default.
• W1973670690 doi "https://doi.org/10.1097/wnr.0b013e328359d990" @default.
• W1973670690 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23032403" @default.
• W1973670690 hasPublicationYear "2012" @default.
• W1973670690 type Work @default.
• W1973670690 sameAs 1973670690 @default.
• W1973670690 citedByCount "25" @default.
• W1973670690 countsByYear W19736706902013 @default.
• W1973670690 countsByYear W19736706902014 @default.
• W1973670690 countsByYear W19736706902015 @default.
• W1973670690 countsByYear W19736706902016 @default.
• W1973670690 countsByYear W19736706902017 @default.
• W1973670690 countsByYear W19736706902018 @default.
• W1973670690 countsByYear W19736706902019 @default.
• W1973670690 countsByYear W19736706902020 @default.
• W1973670690 countsByYear W19736706902022 @default.
• W1973670690 crossrefType "journal-article" @default.
• W1973670690 hasAuthorship W1973670690A5022667013 @default.
• W1973670690 hasAuthorship W1973670690A5048725628 @default.
• W1973670690 hasAuthorship W1973670690A5055522939 @default.
• W1973670690 hasConcept C102747710 @default.
• W1973670690 hasConcept C104317684 @default.
• W1973670690 hasConcept C106987784 @default.
• W1973670690 hasConcept C130316041 @default.
• W1973670690 hasConcept C143065580 @default.
• W1973670690 hasConcept C148785051 @default.
• W1973670690 hasConcept C167019083 @default.
• W1973670690 hasConcept C169760540 @default.
• W1973670690 hasConcept C185592680 @default.
• W1973670690 hasConcept C20418707 @default.
• W1973670690 hasConcept C2781427258 @default.
• W1973670690 hasConcept C41625074 @default.
• W1973670690 hasConcept C55493867 @default.
• W1973670690 hasConcept C59006786 @default.
• W1973670690 hasConcept C70192387 @default.
• W1973670690 hasConcept C79879829 @default.
• W1973670690 hasConcept C86803240 @default.
• W1973670690 hasConcept C95444343 @default.
• W1973670690 hasConceptScore W1973670690C102747710 @default.
• W1973670690 hasConceptScore W1973670690C104317684 @default.
• W1973670690 hasConceptScore W1973670690C106987784 @default.
• W1973670690 hasConceptScore W1973670690C130316041 @default.
• W1973670690 hasConceptScore W1973670690C143065580 @default.
• W1973670690 hasConceptScore W1973670690C148785051 @default.
• W1973670690 hasConceptScore W1973670690C167019083 @default.
• W1973670690 hasConceptScore W1973670690C169760540 @default.
• W1973670690 hasConceptScore W1973670690C185592680 @default.
• W1973670690 hasConceptScore W1973670690C20418707 @default.
• W1973670690 hasConceptScore W1973670690C2781427258 @default.
• W1973670690 hasConceptScore W1973670690C41625074 @default.
• W1973670690 hasConceptScore W1973670690C55493867 @default.
• W1973670690 hasConceptScore W1973670690C59006786 @default.
• W1973670690 hasConceptScore W1973670690C70192387 @default.
• W1973670690 hasConceptScore W1973670690C79879829 @default.
• W1973670690 hasConceptScore W1973670690C86803240 @default.
• W1973670690 hasConceptScore W1973670690C95444343 @default.
• W1973670690 hasIssue "16" @default.
• W1973670690 hasLocation W19736706901 @default.
• W1973670690 hasLocation W19736706902 @default.
• W1973670690 hasOpenAccess W1973670690 @default.
• W1973670690 hasPrimaryLocation W19736706901 @default.
• W1973670690 hasRelatedWork W1963836683 @default.
• W1973670690 hasRelatedWork W1965675171 @default.
• W1973670690 hasRelatedWork W1973670690 @default.
• W1973670690 hasRelatedWork W2002404265 @default.
• W1973670690 hasRelatedWork W2122261008 @default.
• W1973670690 hasRelatedWork W2740263091 @default.
• W1973670690 hasRelatedWork W3004902701 @default.

• next