FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1973673217> ?p ?o ?g. }

• W1973673217 endingPage "1449" @default.
• W1973673217 startingPage "1442" @default.
• W1973673217 abstract "Excessive inflammation can lead to tissue damage and dysfunction of vital organs. Hence, regulating inflammatory response is a viable therapeutic approach. In Asian countries, various inflammatory diseases have often effectively been treated with herbal remedies including the root extract of Aralia continentalis Kitagawa (Araliaceae). Here, we investigated the effect of kaurenoic acid (ent-kaur-16-en-19-oic acid: KA), a diterpenoid that is extracted from Aralia continentalis Kitagawa root, on inflammation.Western blot and RT-PCR analyses show that KA induced the nuclear localization of Nrf2 as low as 1 nM in concentration and that KA treatment induced the expression of Nrf2 dependent genes such as GCLC and HO-1. On the other hand, KA did not affect the degradation of cytoplasmic IκB-α, the nuclear localization of RelA (p65), and NF-κB transcriptional activity in RAW264.7 cells treated with endotoxin. Consistent with these data, KA treatment failed to suppress gene expression of representative pro-inflammatory mediators including COX-2, nitric oxide, IL-1β, TNF-α, and IL-12, indicating that KA did not have an important impact on NF-κB activation.Together, these results show that KA was an effective activator of Nrf2, and suggest that the beneficial effects of Aralia continentalis Kitagawa root extract are, at least in part, mediated by activating Nrf2." @default.
• W1973673217 created "2016-06-24" @default.
• W1973673217 creator A5002575123 @default.
• W1973673217 creator A5003183399 @default.
• W1973673217 creator A5006787063 @default.
• W1973673217 creator A5008043632 @default.
• W1973673217 creator A5021338267 @default.
• W1973673217 creator A5030106870 @default.
• W1973673217 creator A5043882385 @default.
• W1973673217 creator A5047092703 @default.
• W1973673217 creator A5051453892 @default.
• W1973673217 creator A5061782425 @default.
• W1973673217 creator A5062312160 @default.
• W1973673217 creator A5066440299 @default.
• W1973673217 creator A5070150026 @default.
• W1973673217 creator A5072029019 @default.
• W1973673217 creator A5081819707 @default.
• W1973673217 date "2011-10-01" @default.
• W1973673217 modified "2023-10-06" @default.
• W1973673217 title "ent-kaur-16-en-19-oic acid, isolated from the roots of Aralia continentalis, induces activation of Nrf2" @default.
• W1973673217 cites W1481223048 @default.
• W1973673217 cites W1874333181 @default.
• W1973673217 cites W1967421499 @default.
• W1973673217 cites W1969385219 @default.
• W1973673217 cites W1972825345 @default.
• W1973673217 cites W2005242193 @default.
• W1973673217 cites W2029452394 @default.
• W1973673217 cites W2030515433 @default.
• W1973673217 cites W2044911368 @default.
• W1973673217 cites W2048700223 @default.
• W1973673217 cites W2052548231 @default.
• W1973673217 cites W2060004156 @default.
• W1973673217 cites W2062145087 @default.
• W1973673217 cites W2064452102 @default.
• W1973673217 cites W2065071225 @default.
• W1973673217 cites W2074171762 @default.
• W1973673217 cites W2077759279 @default.
• W1973673217 cites W2086662467 @default.
• W1973673217 cites W2087660898 @default.
• W1973673217 cites W2094156327 @default.
• W1973673217 cites W2103010344 @default.
• W1973673217 cites W2109961974 @default.
• W1973673217 cites W2113024198 @default.
• W1973673217 cites W2122459539 @default.
• W1973673217 cites W2127361574 @default.
• W1973673217 cites W2129726289 @default.
• W1973673217 cites W2134703818 @default.
• W1973673217 cites W2138270333 @default.
• W1973673217 cites W2155383113 @default.
• W1973673217 cites W2164552211 @default.
• W1973673217 cites W3194349304 @default.
• W1973673217 cites W4234756901 @default.
• W1973673217 cites W4242171500 @default.
• W1973673217 doi "https://doi.org/10.1016/j.jep.2011.08.024" @default.
• W1973673217 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3616193" @default.
• W1973673217 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21884778" @default.
• W1973673217 hasPublicationYear "2011" @default.
• W1973673217 type Work @default.
• W1973673217 sameAs 1973673217 @default.
• W1973673217 citedByCount "47" @default.
• W1973673217 countsByYear W19736732172012 @default.
• W1973673217 countsByYear W19736732172013 @default.
• W1973673217 countsByYear W19736732172014 @default.
• W1973673217 countsByYear W19736732172015 @default.
• W1973673217 countsByYear W19736732172016 @default.
• W1973673217 countsByYear W19736732172017 @default.
• W1973673217 countsByYear W19736732172018 @default.
• W1973673217 countsByYear W19736732172019 @default.
• W1973673217 countsByYear W19736732172020 @default.
• W1973673217 countsByYear W19736732172021 @default.
• W1973673217 countsByYear W19736732172022 @default.
• W1973673217 countsByYear W19736732172023 @default.
• W1973673217 crossrefType "journal-article" @default.
• W1973673217 hasAuthorship W1973673217A5002575123 @default.
• W1973673217 hasAuthorship W1973673217A5003183399 @default.
• W1973673217 hasAuthorship W1973673217A5006787063 @default.
• W1973673217 hasAuthorship W1973673217A5008043632 @default.
• W1973673217 hasAuthorship W1973673217A5021338267 @default.
• W1973673217 hasAuthorship W1973673217A5030106870 @default.
• W1973673217 hasAuthorship W1973673217A5043882385 @default.
• W1973673217 hasAuthorship W1973673217A5047092703 @default.
• W1973673217 hasAuthorship W1973673217A5051453892 @default.
• W1973673217 hasAuthorship W1973673217A5061782425 @default.
• W1973673217 hasAuthorship W1973673217A5062312160 @default.
• W1973673217 hasAuthorship W1973673217A5066440299 @default.
• W1973673217 hasAuthorship W1973673217A5070150026 @default.
• W1973673217 hasAuthorship W1973673217A5072029019 @default.
• W1973673217 hasAuthorship W1973673217A5081819707 @default.
• W1973673217 hasBestOaLocation W19736732172 @default.
• W1973673217 hasConcept C104317684 @default.
• W1973673217 hasConcept C142724271 @default.
• W1973673217 hasConcept C178790620 @default.
• W1973673217 hasConcept C185592680 @default.
• W1973673217 hasConcept C203014093 @default.
• W1973673217 hasConcept C204787440 @default.
• W1973673217 hasConcept C2776415932 @default.
• W1973673217 hasConcept C2776914184 @default.
• W1973673217 hasConcept C2777622882 @default.

• next