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- W1973676386 abstract "Bacteria belonging to the Enterobacteriaceae family that produce extended-spectrum β -lactamase (ESBL) enzymes are important pathogens of infections. Increasing numbers of ESBL-producing bacterial strains exhibiting multidrug resistance have been observed. The aim of the study was to evaluate the prevalence of<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M1><mml:mi>b</mml:mi><mml:mi>l</mml:mi><mml:msub><mml:mrow><mml:mi>a</mml:mi></mml:mrow><mml:mrow><mml:mtext>CTX-M</mml:mtext></mml:mrow></mml:msub></mml:math>,<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M2><mml:mi>b</mml:mi><mml:mi>l</mml:mi><mml:msub><mml:mrow><mml:mi>a</mml:mi></mml:mrow><mml:mrow><mml:mtext>SHV</mml:mtext></mml:mrow></mml:msub></mml:math>, and<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M3><mml:mi>b</mml:mi><mml:mi>l</mml:mi><mml:msub><mml:mrow><mml:mi>a</mml:mi></mml:mrow><mml:mrow><mml:mtext>TEM</mml:mtext></mml:mrow></mml:msub></mml:math>genes among ESBL-producing Klebsiella pneumoniae , Escherichia coli , and Proteus mirabilis strains and to examine susceptibility to antibiotics of tested strains. In our study, thirty-six of the tested strains exhibited<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M4><mml:mi>b</mml:mi><mml:mi>l</mml:mi><mml:msub><mml:mrow><mml:mi>a</mml:mi></mml:mrow><mml:mrow><mml:mtext>CTX-M</mml:mtext></mml:mrow></mml:msub></mml:math>genes<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M5><mml:mo stretchy=false>(</mml:mo><mml:mi>b</mml:mi><mml:mi>l</mml:mi><mml:msub><mml:mrow><mml:mi>a</mml:mi></mml:mrow><mml:mrow><mml:mtext>CTX-M-15</mml:mtext></mml:mrow></mml:msub></mml:math>,<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M6><mml:mi>b</mml:mi><mml:mi>l</mml:mi><mml:msub><mml:mrow><mml:mi>a</mml:mi></mml:mrow><mml:mrow><mml:mtext>CTX-M-3</mml:mtext></mml:mrow></mml:msub></mml:math>,<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M7><mml:mi>b</mml:mi><mml:mi>l</mml:mi><mml:msub><mml:mrow><mml:mi>a</mml:mi></mml:mrow><mml:mrow><mml:mtext>CTX-M-91</mml:mtext></mml:mrow></mml:msub></mml:math>, and<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M8><mml:mi>b</mml:mi><mml:mi>l</mml:mi><mml:msub><mml:mrow><mml:mi>a</mml:mi></mml:mrow><mml:mrow><mml:mtext>CTX-M-89</mml:mtext></mml:mrow></mml:msub><mml:mo stretchy=false>)</mml:mo></mml:math>. Moreover, twelve ESBL-positive strains harbored<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M9><mml:mi>b</mml:mi><mml:mi>l</mml:mi><mml:msub><mml:mrow><mml:mi>a</mml:mi></mml:mrow><mml:mrow><mml:mtext>SHV</mml:mtext></mml:mrow></mml:msub></mml:math>genes<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M10><mml:mo stretchy=false>(</mml:mo><mml:mi>b</mml:mi><mml:mi>l</mml:mi><mml:msub><mml:mrow><mml:mi>a</mml:mi></mml:mrow><mml:mrow><mml:mtext>SHV-18</mml:mtext></mml:mrow></mml:msub></mml:math>,<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M11><mml:mi>b</mml:mi><mml:mi>l</mml:mi><mml:msub><mml:mrow><mml:mi>a</mml:mi></mml:mrow><mml:mrow><mml:mtext>SHV-7</mml:mtext></mml:mrow></mml:msub></mml:math>,<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M12><mml:mi>b</mml:mi><mml:mi>l</mml:mi><mml:msub><mml:mrow><mml:mi>a</mml:mi></mml:mrow><mml:mrow><mml:mtext>SHV-2</mml:mtext></mml:mrow></mml:msub></mml:math>, and<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M13><mml:mi>b</mml:mi><mml:mi>l</mml:mi><mml:msub><mml:mrow><mml:mi>a</mml:mi></mml:mrow><mml:mrow><mml:mtext>SHV-5</mml:mtext></mml:mrow></mml:msub><mml:mo stretchy=false>)</mml:mo></mml:math>, and the presence of a<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M14><mml:mi>b</mml:mi><mml:mi>l</mml:mi><mml:msub><mml:mrow><mml:mi>a</mml:mi></mml:mrow><mml:mrow><mml:mtext>TEM</mml:mtext></mml:mrow></mml:msub></mml:math>gene<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M15><mml:mo stretchy=false>(</mml:mo><mml:mi>b</mml:mi><mml:mi>l</mml:mi><mml:msub><mml:mrow><mml:mi>a</mml:mi></mml:mrow><mml:mrow><mml:mtext>TEM-1</mml:mtext></mml:mrow></mml:msub><mml:mo stretchy=false>)</mml:mo></mml:math>in twenty-five ESBL-positive strains was revealed. Among K. pneumoniae the multiple ESBL genotype composed of<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M16><mml:mi>b</mml:mi><mml:mi>l</mml:mi><mml:msub><mml:mrow><mml:mi>a</mml:mi></mml:mrow><mml:mrow><mml:mtext>CTX-M-15</mml:mtext></mml:mrow></mml:msub><mml:mo>,</mml:mo><mml:mi> </mml:mi><mml:mi>b</mml:mi><mml:mi>l</mml:mi><mml:msub><mml:mrow><mml:mi>a</mml:mi></mml:mrow><mml:mrow><mml:mtext>CTX-M-3</mml:mtext></mml:mrow></mml:msub><mml:mo>,</mml:mo><mml:mi> </mml:mi><mml:mi>b</mml:mi><mml:mi>l</mml:mi><mml:msub><mml:mrow><mml:mi>a</mml:mi></mml:mrow><mml:mrow><mml:mtext>SHV-18</mml:mtext></mml:mrow></mml:msub><mml:mo>,</mml:mo><mml:mi> </mml:mi><mml:mi>b</mml:mi><mml:mi>l</mml:mi><mml:msub><mml:mrow><mml:mi>a</mml:mi></mml:mrow><mml:mrow><mml:mtext>SHV-7</mml:mtext></mml:mrow></mml:msub><mml:mo>,</mml:mo><mml:mi> </mml:mi><mml:mi>b</mml:mi><mml:mi>l</mml:mi><mml:msub><mml:mrow><mml:mi>a</mml:mi></mml:mrow><mml:mrow><mml:mtext>SHV-2</mml:mtext></mml:mrow></mml:msub></mml:math>, and<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M17><mml:mi>b</mml:mi><mml:mi>l</mml:mi><mml:msub><mml:mrow><mml:mi>a</mml:mi></mml:mrow><mml:mrow><mml:mtext>SHV-5</mml:mtext></mml:mrow></mml:msub></mml:math>genes encoding particular ESBL variants was observed. Analysis of bacterial susceptibility to antibiotics revealed that, among β -lactam antibiotics, the most effective against E. coli strains was meropenem (100%), whereas K. pneumoniae were completely susceptible to ertapenem and meropenem (100%), and P. mirabilis strains were susceptible to ertapenem (91.7%). Moreover, among non- β -lactam antibiotics, gentamicin showed the highest activity to E. coli (91.7%) and ciprofloxacin the highest to K. pneumoniae (83.3%). P. mirabilis revealed the highest susceptibility to amikacin (66.7%)." @default.
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- W1973676386 title "The Occurrence of<i>bla</i><sub>CTX-M</sub>,<i>bla</i><sub>SHV</sub>, and<i>bla</i><sub>TEM</sub>Genes in Extended-Spectrum<i>β</i>-Lactamase-Positive Strains of<i>Klebsiella pneumoniae</i>,<i>Escherichia coli</i>, and<i>Proteus mirabilis</i>in Poland" @default.
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