Matches in SemOpenAlex for { <https://semopenalex.org/work/W1973683350> ?p ?o ?g. }
- W1973683350 endingPage "294" @default.
- W1973683350 startingPage "285" @default.
- W1973683350 abstract "Protein kinase C delta (PKCδ), a PKC family isoform, regulates diverse signal transduction pathways during DNA damage to induce apoptosis. To explore the apoptosis mechanism that PKCδ modulates, we sought to uncover transcription factor targets of PKCδ by devising a screening strategy that utilizes ChIP-cloning and microarray analysis. Transcription factor candidates were generated with the application of public access data-mining tools and this resulted in the identification of Evi-1 as a novel PKCδ-mediated DNA damage responsive molecule. The results demonstrated that PKCδ is constitutively associated with Evi-1. PKCδ regulated Evi-1 to activate PLZF transcription upon genotoxic stress. Furthermore, both Evi-1 and PLZF were associated with DNA damage-stimulated apoptosis. Taken together, we have discovered a novel regulation of Evi-1, which transactivates PLZF, by PKCδ to induce cell death in response to genotoxic stress." @default.
- W1973683350 created "2016-06-24" @default.
- W1973683350 creator A5030946091 @default.
- W1973683350 creator A5031695335 @default.
- W1973683350 creator A5054622071 @default.
- W1973683350 creator A5059199772 @default.
- W1973683350 creator A5074043103 @default.
- W1973683350 creator A5091623593 @default.
- W1973683350 date "2011-07-01" @default.
- W1973683350 modified "2023-10-16" @default.
- W1973683350 title "Identification of Evi-1 as a novel effector of PKCδ in the apoptotic response to DNA damage" @default.
- W1973683350 cites W1480801258 @default.
- W1973683350 cites W1489169196 @default.
- W1973683350 cites W1532882622 @default.
- W1973683350 cites W1538433900 @default.
- W1973683350 cites W1578441131 @default.
- W1973683350 cites W188006079 @default.
- W1973683350 cites W1975478837 @default.
- W1973683350 cites W1976769209 @default.
- W1973683350 cites W1977825177 @default.
- W1973683350 cites W1981859725 @default.
- W1973683350 cites W1990683309 @default.
- W1973683350 cites W1993720756 @default.
- W1973683350 cites W1996495774 @default.
- W1973683350 cites W2001760728 @default.
- W1973683350 cites W2016420793 @default.
- W1973683350 cites W2018394492 @default.
- W1973683350 cites W2028403985 @default.
- W1973683350 cites W2039081870 @default.
- W1973683350 cites W2045938138 @default.
- W1973683350 cites W2048657955 @default.
- W1973683350 cites W2051223687 @default.
- W1973683350 cites W2051599584 @default.
- W1973683350 cites W2058983867 @default.
- W1973683350 cites W2063014741 @default.
- W1973683350 cites W2064342757 @default.
- W1973683350 cites W2071198627 @default.
- W1973683350 cites W2073738799 @default.
- W1973683350 cites W2076198736 @default.
- W1973683350 cites W2082724854 @default.
- W1973683350 cites W2095510686 @default.
- W1973683350 cites W2106065518 @default.
- W1973683350 cites W2109815943 @default.
- W1973683350 cites W2110817748 @default.
- W1973683350 cites W2126681184 @default.
- W1973683350 cites W2131613604 @default.
- W1973683350 cites W2133037422 @default.
- W1973683350 cites W2133991390 @default.
- W1973683350 cites W2136144485 @default.
- W1973683350 cites W2155508906 @default.
- W1973683350 cites W2162540931 @default.
- W1973683350 cites W2167571277 @default.
- W1973683350 cites W2317413050 @default.
- W1973683350 cites W2322323638 @default.
- W1973683350 cites W2419099630 @default.
- W1973683350 cites W954261861 @default.
- W1973683350 doi "https://doi.org/10.1016/j.bbagrm.2011.02.004" @default.
- W1973683350 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21362509" @default.
- W1973683350 hasPublicationYear "2011" @default.
- W1973683350 type Work @default.
- W1973683350 sameAs 1973683350 @default.
- W1973683350 citedByCount "6" @default.
- W1973683350 countsByYear W19736833502012 @default.
- W1973683350 countsByYear W19736833502013 @default.
- W1973683350 countsByYear W19736833502014 @default.
- W1973683350 countsByYear W19736833502016 @default.
- W1973683350 countsByYear W19736833502018 @default.
- W1973683350 crossrefType "journal-article" @default.
- W1973683350 hasAuthorship W1973683350A5030946091 @default.
- W1973683350 hasAuthorship W1973683350A5031695335 @default.
- W1973683350 hasAuthorship W1973683350A5054622071 @default.
- W1973683350 hasAuthorship W1973683350A5059199772 @default.
- W1973683350 hasAuthorship W1973683350A5074043103 @default.
- W1973683350 hasAuthorship W1973683350A5091623593 @default.
- W1973683350 hasConcept C104317684 @default.
- W1973683350 hasConcept C134935766 @default.
- W1973683350 hasConcept C143425029 @default.
- W1973683350 hasConcept C153911025 @default.
- W1973683350 hasConcept C190283241 @default.
- W1973683350 hasConcept C195794163 @default.
- W1973683350 hasConcept C51785407 @default.
- W1973683350 hasConcept C53345823 @default.
- W1973683350 hasConcept C54355233 @default.
- W1973683350 hasConcept C552990157 @default.
- W1973683350 hasConcept C62478195 @default.
- W1973683350 hasConcept C86339819 @default.
- W1973683350 hasConcept C86803240 @default.
- W1973683350 hasConcept C95444343 @default.
- W1973683350 hasConceptScore W1973683350C104317684 @default.
- W1973683350 hasConceptScore W1973683350C134935766 @default.
- W1973683350 hasConceptScore W1973683350C143425029 @default.
- W1973683350 hasConceptScore W1973683350C153911025 @default.
- W1973683350 hasConceptScore W1973683350C190283241 @default.
- W1973683350 hasConceptScore W1973683350C195794163 @default.
- W1973683350 hasConceptScore W1973683350C51785407 @default.
- W1973683350 hasConceptScore W1973683350C53345823 @default.
- W1973683350 hasConceptScore W1973683350C54355233 @default.
- W1973683350 hasConceptScore W1973683350C552990157 @default.