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- W1973686465 abstract "A variety of evidence has pointed to immunological involvement in the pathogenesis of alopecia areata (AA). The aim of the present study was to determine whether differential expression of HLA-DR and intracellular adhesion molecules-1 (ICAM-1) occurs in hair structures of patients with longstanding AA, following stimulation with interferon-γ (IFN-γ). IFN-γ was injected i.v. to nude mice grafted with transplants obtained from affected areas of seven patients and of normal individuals. All mice were injected with IFN-γ or phosphate-buffered saline (PBS) alone for 3 consecutive days. Immunohistochemical studies were performed in specimens of grafts in order to detect the change in adhesion molecules, HLA-DR antigen, and Langerhans cells. ICAM-1 and HLA-DR induction was found to be similar in grafts from AA patients and normal skin grafts in the IFN-γ injected mice. However, more intraepithelial Langerhans cells were observed in the AA patients' grafts treated with INF-γ than in those treated with PBS and in normal grafts treated with INF-γ. This study suggests an important role of Langerhans cells in this issue." @default.
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- W1973686465 date "1993-02-01" @default.
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- W1973686465 title "Response of Grafts from Patients with Alopecia Areata Transplanted onto Nude Mice, to Administration of Interferon-γ" @default.
- W1973686465 doi "https://doi.org/10.1006/clin.1993.1015" @default.
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