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- W1973698960 abstract "Pregnancy-Induced Hypertension (PIH) a leading causes of perinatal morbidity and mortality. Although the pathogenesis of PIH is poorly understood, numerous reports support the hypothesis that aberrant pro-inflammatory cytokine production and endothelial dysfunction within the placenta mediate PIH development. While smoking during pregnancy is associated with many adverse effects, several studies show that smoking protects against the development of PIH. Based on recent studies revealing the anti-inflammatory properties of nicotine, we have examined the effect of nicotine on inflammatory cytokine production by human placenta cells in vitro. Anonymous human placentas (free of gross abnormalities) were processed within 3 hr of delivery to isolate placenta cells. Placenta cells (2 × 10-6 cells/ml in 96 well plates) were treated with nicotine 10−4M to 10−8M for 30 min prior to LPS stimulation (1-100 ng/ml). After an overnight incubation, cell culture supernatants were collected and assayed for TNF production by ELISA. Statistical significance was determined by ANOVA followed by Tukey post hoc analysis to make pairwise comparisons. LPS (1-1000 ng/ml) stimulation induced a dose-dependent production of the pro-inflammatory mediator, TNF, by human placenta cells. Nicotine (10−4M to 10−5M) significantly reduced TNF production by placenta cells, with the greatest reduction (up to 45%) observed at 10−4M nicotine. Our observations reveal that nicotine inhibits pro-inflammatory cytokine production by placenta cells in vitro. This finding is consistent with studies demonstrating the anti-inflammatory effects of nicotine in numerous pathological conditions, including ulcerative colitis, experimental sepsis, and experimental ileus. Our results suggest a mechanism by which smoking may protect against the development of PIH." @default.
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- W1973698960 date "2005-12-01" @default.
- W1973698960 modified "2023-10-18" @default.
- W1973698960 title "Nicotine suppresses pro-inflammatory responses by human placental cells" @default.
- W1973698960 doi "https://doi.org/10.1016/j.ajog.2005.10.554" @default.
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