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- W1973700190 abstract "BALB/c mice develop aberrant T helper 2 (Th2) responses and suffer progressive disease after infection with Leishmania major. These outcomes depend on the production of interleukin-4 (IL-4) early after infection. Here we demonstrate that the burst of IL-4 mRNA, peaking in draining lymph nodes of BALB/c mice 16 hr after infection, occurs within CD4+ T cells that express Vβ4 Vα8 T cell receptors. In contrast to control and Vβ6-deficient BALB/c mice, Vβ4-deficient BALB/c mice were resistant to infection, demonstrating the role of these cells in Th2 development. The early IL-4 response was absent in these mice, and T helper 1 responses occurred following infection. Recombinant LACK antigen from L. major induced comparable IL-4 production in Vβ4 Vα8 CD4+ cells. Thus, the IL-4 required for Th2 development and susceptibility to L. major is produced by a restricted population of Vβ4 Vα8 CD4+ T cells after cognate interaction with a single antigen from this complex organism." @default.
- W1973700190 created "2016-06-24" @default.
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- W1973700190 date "1997-05-01" @default.
- W1973700190 modified "2023-10-18" @default.
- W1973700190 title "IL-4 Rapidly Produced by Vβ4 Vα8 CD4+ T Cells Instructs Th2 Development and Susceptibility to Leishmania major in BALB/c Mice" @default.
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- W1973700190 doi "https://doi.org/10.1016/s1074-7613(00)80342-8" @default.
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