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• W1973702005 abstract "All cancers originate from a single cell that starts to behave abnormally due to the acquired somatic mutations in its genome. Until recently, the knowledge of the mutational processes that cause these somatic mutations has been very limited. Recent advances in sequencing technologies and the development of novel mathematical approaches have allowed deciphering the patterns of somatic mutations caused by different mutational processes. Here, we summarize our current understanding of mutational patterns and mutational signatures in light of both the somatic cell paradigm of cancer research and the recent developments in the field of cancer genomics." @default.
• W1973702005 created "2016-06-24" @default.
• W1973702005 creator A5058103562 @default.
• W1973702005 creator A5080997789 @default.
• W1973702005 date "2014-02-01" @default.
• W1973702005 modified "2023-10-10" @default.
• W1973702005 title "Mutational signatures: the patterns of somatic mutations hidden in cancer genomes" @default.
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• W1973702005 doi "https://doi.org/10.1016/j.gde.2013.11.014" @default.
• W1973702005 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3990474" @default.
• W1973702005 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24657537" @default.
• W1973702005 hasPublicationYear "2014" @default.
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