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- W1973702966 abstract "The application of coupled-column liquid chromatographic analysis to pharmacokinetic studies eliminates the need for sample clean-up from plasma. Considering lipophilic antineoplastic agents, we tested this approach to analyze paclitaxel under unfavourable circumstances (i.e., weekly low-dose regimen, plasma protein binding >90%, UV detection at 229 nm). The excellent quality control data (recovery: 95.6-100.7%, inter-assay relative standard deviation on 5 days: 1.3-3.2%, accuracy: 0.9-2.7%) and the detection limit of 19 nM indicates the usefulness of this method for the analysis of paclitaxel in plasma using on-line solid-phase extraction." @default.
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- W1973702966 date "2002-04-01" @default.
- W1973702966 modified "2023-09-25" @default.
- W1973702966 title "On-line solid-phase extraction and determination of paclitaxel in human plasma" @default.
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- W1973702966 doi "https://doi.org/10.1016/s1570-0232(02)00025-9" @default.
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