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- W1973703095 abstract "Progenitors are early lineage cells that proliferate before the onset of terminal differentiation. Although widespread, the epigenetic mechanisms that control the progenitor state and the onset of differentiation remain elusive. By studying Drosophila ovarian follicle cell progenitors, we identified lysine-specific demethylase 1 ( lsd1 ) and CoRest as differentiation regulators using a GAL4∷GFP variegation assay. The follicle cell progenitors in lsd1 or CoRest heterozygotes prematurely lose epigenetic plasticity, undergo the Notch-dependent mitotic-endocycle transition, and stop dividing before a normal number of follicle cells can be produced. Simultaneously reducing the dosage of the histone H3K4 methyltransferase Trithorax reverses these effects, suggesting that an Lsd1/CoRest complex times progenitor differentiation by controlling the stability of H3K4 methylation levels. Individual cells or small clones initially respond to Notch; hence, a critical level of epigenetic stabilization is acquired cell-autonomously and initiates differentiation by making progenitors responsive to pre-existing external signals." @default.
- W1973703095 created "2016-06-24" @default.
- W1973703095 creator A5007819414 @default.
- W1973703095 creator A5016264819 @default.
- W1973703095 date "2014-12-15" @default.
- W1973703095 modified "2023-09-25" @default.
- W1973703095 title "The progenitor state is maintained by <i>lysine-specific demethylase 1</i>-mediated epigenetic plasticity during <i>Drosophila</i> follicle cell development" @default.
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- W1973703095 doi "https://doi.org/10.1101/gad.252692.114" @default.
- W1973703095 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4265677" @default.
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