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- W1973711222 abstract "To measure oxidative DNA and lipid damages, urinary levels of 8-hydroxy-2'-deoxyguanosine (8-OHdG), and 8-isoprostane in esophageal squamous cell carcinoma (SCC) patients and compare the values with that in controls.The urinary concentrations of 8-OHdG and 8-isoprostane were measured in 32 SCC patients (13 female/19 male; mean age: 61.4 ± 10.5 years) and 45 controls (22 female/23 male; mean age: 58.1 ± 8.3 years).Squamous cell carcinoma patients showed significantly higher levels of urinary 8-OHdG (15.6 ± 5.1 ng/mg creatinine) than controls (5.8 ± 2.1 ng/mg creatinine) (P<.001). Increased urinary concentrations of 8-isoprostane were also detected in SCC patients (35.4 ± 6.5 ng/mmol creatinine) as compared to the controls (16.9 ± 4.0 ng/mmol creatinine) (P<.001).Our results show the presence of oxidative DNA and lipid damage in the SCC patients. This may have a connection to carcinogenesis in the esophagus." @default.
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- W1973711222 date "2011-01-01" @default.
- W1973711222 modified "2023-10-04" @default.
- W1973711222 title "Elevated levels of urinary 8-hydroxy-2Ͳ-deoxyguanosine and 8-isoprostane in esophageal squamous cell carcinoma" @default.
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- W1973711222 doi "https://doi.org/10.4103/1477-3163.79683" @default.
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