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• W1973712279 endingPage "41" @default.
• W1973712279 startingPage "29" @default.
• W1973712279 abstract "Both anatomical and physiological mapping methods have revealed that the mammalian cerebellar cortex consists of a family of parasagittal bands of cells, each band with its own pattern of afferent and efferent axons. Monoclonal antibody mabQ113 recognizes an unknown polypeptide antigen that is confined to a subset of rat cerebellar Purkinje cells. Immunoreactive cells are arranged into parasagittal bands extending throughout the vermis and hemispheres. Expression of the Q113 epitope by individual Purkinje cells may not be all-or-nothing, since the bands tend to be more strongly stained in the vermis than the hemispheres. The band display is symmetrical about the midline and reproducible from individual to individual. Wholemount immunocytochemistry and serial reconstruction reveal a median band of mabQ113+ Purkinje cells adjacent to the midline (P1 + ) and six other positive bands disposed symmetrically at either side (P2+ to P7 + ). Bands are distinct throughout most of the cortex but tend to fuse ventrally and caudally. There are two sources of interindividual differences. Firstly, most animals express supernumerary “satellite” bands in the vermis. Satellite bands are usually only one cell wide, are not bilaterally symmetrical, and differ in position and number from individual to individual. Secondly, the precise position of an individual band can differ, perhaps according to the variable cortical lobulation, for example, the position of P4+ in lobules VIII/IX and P6+ in lobule VII. While a scheme of parasagittal bands is a good description of the vermian organization, the distribution of mabQ113+ and mabQ113- Purkinje cells in the hemispheres may be better described as a checkerboard of antigenic patches." @default.
• W1973712279 created "2016-06-24" @default.
• W1973712279 creator A5016523750 @default.
• W1973712279 creator A5029363688 @default.
• W1973712279 date "1987-02-01" @default.
• W1973712279 modified "2023-09-30" @default.
• W1973712279 title "Antigenic map of the rat cerebellar cortex: The distribution of parasagittal bands as revealed by monoclonal anti-purkinje cell antibody mabQ113" @default.
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• W1973712279 doi "https://doi.org/10.1002/cne.902560104" @default.
• W1973712279 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3546410" @default.
• W1973712279 hasPublicationYear "1987" @default.
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