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• W1973722221 abstract "The infectivity of gametocytes to the mosquito vector decreases dramatically during the early phase of plasmodial infection despite an increase in the number of gametocytes. The present study was aimed to clarify the mechanism of this natural transmission-blocking by using the murine malaria parasite, Plasmodium yoelii. The development of cultured gametocytes taken from the mice on days 4 and 5 after infection was significantly impaired; however, gametocytes taken from the mice on day 3 developed normally into ookinetes. These results indicated that the gametocyte infectivity was already lost in the infected host. The contribution of nitric oxide to diminished gametocyte infectivity was confirmed using L-NMMA, a selective inhibitor of nitric oxide synthase, and NOC5, a nitric oxide donor. The reduction of oocyst formation was partially reversed on day 4 after P. yoelii infection in the L-NMMA-treated group. The prevalence of infection among mosquitoes fed on mice 5 days after P. yoelii infection increased dramatically by the L-NMMA treatment. Moreover, the number of oocysts per mosquito midgut fed on the NOC5-treated mice infected with P. yoelii significantly decreased; likewise, gamete/zygote formation in vitro was inhibited by the pre-incubation of gametocytes with NOC5 before the gametogenesis. These results suggest that nitric oxide, as an effector molecule, inhibits the development of P. yoelii gametocytes into gametes." @default.
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• W1973722221 date "1998-06-01" @default.
• W1973722221 modified "2023-10-17" @default.
• W1973722221 title "Nitric oxide inhibits the development of Plasmodium yoelii gametocytes into gametes" @default.
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• W1973722221 doi "https://doi.org/10.1016/s1383-5769(98)00014-2" @default.
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