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- W1973726468 abstract "Thirteen strains of Pasteurella haemolytica resistant to moderate levels of trimethoprim (MICs from 8 to 64 μg/ml and 0129 (MICs from 16 to 64 μg/ml) were isolated from bovine specimens. Two strains, CNP330 and CNP334, were studied and found to harbour various plasmids but all attempts to cure trimethoprim resistance were unsuccessful. Resistance characters were not transferable to Escherichia coli or the Pasteurella multocida by conjugation and to E. coli by transformation. The resistance gene(s) was therefore tentatively assigned to a chromosomal location and cloned in E. coli where it conferred trimethoprim resistance. Trans-complementation analysis of a dihydrofolate reductase-deficient mutant of E. coli showed that trimethoprim resistance was secondary to synthesis of a dihydrofolate reductase. DNA/DNA hybridization of the hybrid plasmid and of strains CNP330 and CNP334 with probes specific for dihydrofolate reductase types I to V were negative, indicating that cross-resistance to trimetrhoprim and 0129 in P. haemolytica was due to the acquisition by P. haemolytica of a new resistance determinant." @default.
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- W1973726468 date "1991-01-01" @default.
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- W1973726468 title "Resistance to trimethoprim and 2,4-diamino-6,7-diisopropyl-pteridine (0129) in Pasteurella haemolytica" @default.
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- W1973726468 doi "https://doi.org/10.1016/0378-1135(91)90047-j" @default.
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