Matches in SemOpenAlex for { <https://semopenalex.org/work/W1973740712> ?p ?o ?g. }
- W1973740712 endingPage "15" @default.
- W1973740712 startingPage "1" @default.
- W1973740712 abstract "During mouse preimplantation development, the cells of the mouse embryo undergo a progressive subcellular reorganization at compaction, which eventually results in the formation of two distinct cell types. We have investigated the effect that activators of the Ca2+-phospholipid-dependent protein kinase (PKC) have on mouse compaction. Phorbol ester activation of PKC caused premature compaction of four-cell embryos within a few minutes of addition followed by a prolonged decompaction phase after 1 hr. This response was dose-dependent to concentrations as low as 250 pg/ml. Diacylglycerides also caused compaction; however, it was more sustained than with phorbol esters and was not followed by a phase of decompaction. Inhibition of PKC with sphingosine blocks induced compaction in a dose-dependent manner and also blocks normal compaction of eight-cell embryos. A monoclonal antibody to the cell adhesion molecule, E-cadherin, which mediates mouse embryo compaction, completely blocks compaction induced by these activators of PKC. Indirect immunofluorescence with a monoclonal antibody to E-cadherin indicates that PKC activation causes a rapid shift in the localization of this cell adhesion molecule, which coincides with the observed compaction. These results suggest that PKC plays a role in the initiation of compaction through its effect either directly or indirectly on E-cadherin." @default.
- W1973740712 created "2016-06-24" @default.
- W1973740712 creator A5035344252 @default.
- W1973740712 creator A5043792296 @default.
- W1973740712 creator A5048114193 @default.
- W1973740712 creator A5084943724 @default.
- W1973740712 date "1990-03-01" @default.
- W1973740712 modified "2023-09-28" @default.
- W1973740712 title "Activation of protein kinase C triggers premature compaction in the four-cell stage mouse embryo" @default.
- W1973740712 cites W1488137693 @default.
- W1973740712 cites W1488599557 @default.
- W1973740712 cites W1507801782 @default.
- W1973740712 cites W1521619940 @default.
- W1973740712 cites W1590089681 @default.
- W1973740712 cites W1595133660 @default.
- W1973740712 cites W1602015914 @default.
- W1973740712 cites W1602448176 @default.
- W1973740712 cites W1777807410 @default.
- W1973740712 cites W1933881094 @default.
- W1973740712 cites W1964839077 @default.
- W1973740712 cites W1964947976 @default.
- W1973740712 cites W1964977499 @default.
- W1973740712 cites W1970868451 @default.
- W1973740712 cites W1975953566 @default.
- W1973740712 cites W1977937462 @default.
- W1973740712 cites W1985512165 @default.
- W1973740712 cites W1993282564 @default.
- W1973740712 cites W1996419268 @default.
- W1973740712 cites W2001578819 @default.
- W1973740712 cites W2001692359 @default.
- W1973740712 cites W2002184520 @default.
- W1973740712 cites W2005503398 @default.
- W1973740712 cites W2005966935 @default.
- W1973740712 cites W2012199045 @default.
- W1973740712 cites W2015293062 @default.
- W1973740712 cites W2019480030 @default.
- W1973740712 cites W2021148581 @default.
- W1973740712 cites W2021509469 @default.
- W1973740712 cites W2023978323 @default.
- W1973740712 cites W2031489602 @default.
- W1973740712 cites W2033401875 @default.
- W1973740712 cites W2038197846 @default.
- W1973740712 cites W2045233723 @default.
- W1973740712 cites W2046298157 @default.
- W1973740712 cites W2048990794 @default.
- W1973740712 cites W2060469336 @default.
- W1973740712 cites W2061574494 @default.
- W1973740712 cites W2062024980 @default.
- W1973740712 cites W2066416662 @default.
- W1973740712 cites W2073320971 @default.
- W1973740712 cites W2075409024 @default.
- W1973740712 cites W2075781011 @default.
- W1973740712 cites W2076292306 @default.
- W1973740712 cites W2079346360 @default.
- W1973740712 cites W2080383215 @default.
- W1973740712 cites W2081189659 @default.
- W1973740712 cites W2083611460 @default.
- W1973740712 cites W2084951485 @default.
- W1973740712 cites W2090827556 @default.
- W1973740712 cites W2095296343 @default.
- W1973740712 cites W2111072594 @default.
- W1973740712 cites W2119828692 @default.
- W1973740712 cites W2125753461 @default.
- W1973740712 cites W2128034008 @default.
- W1973740712 cites W2136189765 @default.
- W1973740712 cites W2138312252 @default.
- W1973740712 cites W2149687705 @default.
- W1973740712 cites W2165323138 @default.
- W1973740712 cites W2165332793 @default.
- W1973740712 cites W2404106770 @default.
- W1973740712 cites W2413013739 @default.
- W1973740712 cites W979725628 @default.
- W1973740712 doi "https://doi.org/10.1016/0012-1606(90)90171-e" @default.
- W1973740712 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2407575" @default.
- W1973740712 hasPublicationYear "1990" @default.
- W1973740712 type Work @default.
- W1973740712 sameAs 1973740712 @default.
- W1973740712 citedByCount "164" @default.
- W1973740712 countsByYear W19737407122012 @default.
- W1973740712 countsByYear W19737407122013 @default.
- W1973740712 countsByYear W19737407122014 @default.
- W1973740712 countsByYear W19737407122015 @default.
- W1973740712 countsByYear W19737407122016 @default.
- W1973740712 countsByYear W19737407122017 @default.
- W1973740712 countsByYear W19737407122018 @default.
- W1973740712 countsByYear W19737407122019 @default.
- W1973740712 countsByYear W19737407122020 @default.
- W1973740712 countsByYear W19737407122021 @default.
- W1973740712 countsByYear W19737407122022 @default.
- W1973740712 crossrefType "journal-article" @default.
- W1973740712 hasAuthorship W1973740712A5035344252 @default.
- W1973740712 hasAuthorship W1973740712A5043792296 @default.
- W1973740712 hasAuthorship W1973740712A5048114193 @default.
- W1973740712 hasAuthorship W1973740712A5084943724 @default.
- W1973740712 hasConcept C1491633281 @default.
- W1973740712 hasConcept C153911025 @default.
- W1973740712 hasConcept C159654299 @default.
- W1973740712 hasConcept C184235292 @default.