FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1973740860> ?p ?o ?g. }

• W1973740860 endingPage "76" @default.
• W1973740860 startingPage "71" @default.
• W1973740860 abstract "Elevation of blood pressure is a characteristic feature of spontaneous and pharmacologically induced panic attacks in man. We examined whether this symptom could be reproduced in conscious rats and, if so, whether the cardiovascular changes induced by anxiogenic agents could be employed as a functional in vivo screen for CCK-B receptor antagonists which might be predictive of anxiolytic activity. Bolus i.v. administration of pentagastrin (0.1-100 micrograms/kg) or the beta-carboline FG-7142 (0.001-3 mg/kg) caused transient ( < or = 5 min) dose-dependent increases in arterial blood pressure of up to 41 mmHg. The benzodiazepine receptor agonist chlordiazepoxide (10 mg/kg i.v, 15 min previously) attenuated the pressor response induced by either pentagastrin (1 microgram/kg i.v.) or FG-7142 (0.3 mg/kg i.v.). In contrast, the CCK-B receptor antagonist CI-988 (3 mg/kg i.v., 15 min previously) inhibited the pressor response induced by pentagastrin, but not FG-7142. Antagonism of the pressor response elicited by pentagastrin in animals provides a simple method to establish the active dose range for CCK-B receptor antagonists in vivo. Since cardiovascular parameters can be readily monitored in man, this approach may assist in guiding clinical dose ranging studies to establish therapeutically beneficial effect of these compounds in panic disorder." @default.
• W1973740860 created "2016-06-24" @default.
• W1973740860 creator A5012641063 @default.
• W1973740860 creator A5069068117 @default.
• W1973740860 creator A5075106990 @default.
• W1973740860 date "1996-01-01" @default.
• W1973740860 modified "2023-09-26" @default.
• W1973740860 title "Inhibition of pentagastrin-induced pressor response in conscious rats by the CCK-B receptor antagonist CI-988 and chlordiazepoxide" @default.
• W1973740860 cites W1931915342 @default.
• W1973740860 cites W1971176451 @default.
• W1973740860 cites W1981215714 @default.
• W1973740860 cites W1986832734 @default.
• W1973740860 cites W1988274217 @default.
• W1973740860 cites W1999828528 @default.
• W1973740860 cites W2013274371 @default.
• W1973740860 cites W2027119507 @default.
• W1973740860 cites W2034677399 @default.
• W1973740860 cites W2038856965 @default.
• W1973740860 cites W2042161919 @default.
• W1973740860 cites W2046213581 @default.
• W1973740860 cites W2089704433 @default.
• W1973740860 cites W2090076189 @default.
• W1973740860 cites W2091964121 @default.
• W1973740860 cites W2110115314 @default.
• W1973740860 cites W2114910517 @default.
• W1973740860 cites W2132834629 @default.
• W1973740860 cites W25948229 @default.
• W1973740860 doi "https://doi.org/10.1016/0167-0115(95)00140-9" @default.
• W1973740860 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8701030" @default.
• W1973740860 hasPublicationYear "1996" @default.
• W1973740860 type Work @default.
• W1973740860 sameAs 1973740860 @default.
• W1973740860 citedByCount "5" @default.
• W1973740860 crossrefType "journal-article" @default.
• W1973740860 hasAuthorship W1973740860A5012641063 @default.
• W1973740860 hasAuthorship W1973740860A5069068117 @default.
• W1973740860 hasAuthorship W1973740860A5075106990 @default.
• W1973740860 hasConcept C126322002 @default.
• W1973740860 hasConcept C134018914 @default.
• W1973740860 hasConcept C150903083 @default.
• W1973740860 hasConcept C170493617 @default.
• W1973740860 hasConcept C185592680 @default.
• W1973740860 hasConcept C205044023 @default.
• W1973740860 hasConcept C207001950 @default.
• W1973740860 hasConcept C2776175493 @default.
• W1973740860 hasConcept C2776525901 @default.
• W1973740860 hasConcept C2776885963 @default.
• W1973740860 hasConcept C2777450907 @default.
• W1973740860 hasConcept C2777504413 @default.
• W1973740860 hasConcept C2777765862 @default.
• W1973740860 hasConcept C2778122271 @default.
• W1973740860 hasConcept C2778325228 @default.
• W1973740860 hasConcept C2778938600 @default.
• W1973740860 hasConcept C2779377912 @default.
• W1973740860 hasConcept C2779422922 @default.
• W1973740860 hasConcept C71924100 @default.
• W1973740860 hasConcept C84393581 @default.
• W1973740860 hasConcept C86803240 @default.
• W1973740860 hasConcept C98274493 @default.
• W1973740860 hasConceptScore W1973740860C126322002 @default.
• W1973740860 hasConceptScore W1973740860C134018914 @default.
• W1973740860 hasConceptScore W1973740860C150903083 @default.
• W1973740860 hasConceptScore W1973740860C170493617 @default.
• W1973740860 hasConceptScore W1973740860C185592680 @default.
• W1973740860 hasConceptScore W1973740860C205044023 @default.
• W1973740860 hasConceptScore W1973740860C207001950 @default.
• W1973740860 hasConceptScore W1973740860C2776175493 @default.
• W1973740860 hasConceptScore W1973740860C2776525901 @default.
• W1973740860 hasConceptScore W1973740860C2776885963 @default.
• W1973740860 hasConceptScore W1973740860C2777450907 @default.
• W1973740860 hasConceptScore W1973740860C2777504413 @default.
• W1973740860 hasConceptScore W1973740860C2777765862 @default.
• W1973740860 hasConceptScore W1973740860C2778122271 @default.
• W1973740860 hasConceptScore W1973740860C2778325228 @default.
• W1973740860 hasConceptScore W1973740860C2778938600 @default.
• W1973740860 hasConceptScore W1973740860C2779377912 @default.
• W1973740860 hasConceptScore W1973740860C2779422922 @default.
• W1973740860 hasConceptScore W1973740860C71924100 @default.
• W1973740860 hasConceptScore W1973740860C84393581 @default.
• W1973740860 hasConceptScore W1973740860C86803240 @default.
• W1973740860 hasConceptScore W1973740860C98274493 @default.
• W1973740860 hasIssue "1" @default.
• W1973740860 hasLocation W19737408601 @default.
• W1973740860 hasLocation W19737408602 @default.
• W1973740860 hasOpenAccess W1973740860 @default.
• W1973740860 hasPrimaryLocation W19737408601 @default.
• W1973740860 hasRelatedWork W1518512325 @default.
• W1973740860 hasRelatedWork W1973606441 @default.
• W1973740860 hasRelatedWork W1973740860 @default.
• W1973740860 hasRelatedWork W2009606758 @default.
• W1973740860 hasRelatedWork W2056454041 @default.
• W1973740860 hasRelatedWork W2056658916 @default.
• W1973740860 hasRelatedWork W2086063725 @default.
• W1973740860 hasRelatedWork W2504779997 @default.
• W1973740860 hasRelatedWork W2748952813 @default.
• W1973740860 hasRelatedWork W3134837140 @default.
• W1973740860 hasVolume "61" @default.
• W1973740860 isParatext "false" @default.

• next