FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1973744346> ?p ?o ?g. }

• W1973744346 endingPage "167" @default.
• W1973744346 startingPage "149" @default.
• W1973744346 abstract "Many physiological and synthetic agents act by occluding the ion conduction pore of ion channels. A hallmark of charged blockers is that their apparent affinity for the pore usually varies with membrane voltage. Two models have been proposed to explain this voltage sensitivity. One model assumes that the charged blocker itself directly senses the transmembrane electric field, i.e., that blocker binding is intrinsically voltage dependent. In the alternative model, the blocker does not directly interact with the electric field; instead, blocker binding acquires voltage dependence solely through the concurrent movement of permeant ions across the field. This latter model may better explain voltage dependence of channel block by large organic compounds that are too bulky to fit into the narrow (usually ion-selective) part of the pore where the electric field is steep. To date, no systematic investigation has been performed to distinguish between these voltage-dependent mechanisms of channel block. The most fundamental characteristic of the extrinsic mechanism, i.e., that block can be rendered voltage independent, remains to be established and formally analyzed for the case of organic blockers. Here, we observe that the voltage dependence of block of a cyclic nucleotide-gated channel by a series of intracellular quaternary ammonium blockers, which are too bulky to traverse the narrow ion selectivity filter, gradually vanishes with extreme depolarization, a predicted feature of the extrinsic voltage dependence model. In contrast, the voltage dependence of block by an amine blocker, which has a smaller diameter and can therefore penetrate into the selectivity filter, follows a Boltzmann function, a predicted feature of the intrinsic voltage dependence model. Additionally, a blocker generates (at least) two blocked states, which, if related serially, may preclude meaningful application of a commonly used approach for investigating channel gating, namely, inferring the properties of the activation gate from the kinetics of channel block." @default.
• W1973744346 created "2016-06-24" @default.
• W1973744346 creator A5041904342 @default.
• W1973744346 creator A5084845875 @default.
• W1973744346 date "2010-01-25" @default.
• W1973744346 modified "2023-10-18" @default.
• W1973744346 title "Intrinsic versus extrinsic voltage sensitivity of blocker interaction with an ion channel pore" @default.
• W1973744346 cites W1974558586 @default.
• W1973744346 cites W1975990281 @default.
• W1973744346 cites W1979694517 @default.
• W1973744346 cites W1986849239 @default.
• W1973744346 cites W1990413017 @default.
• W1973744346 cites W1996309216 @default.
• W1973744346 cites W1996790531 @default.
• W1973744346 cites W1997162725 @default.
• W1973744346 cites W2001974484 @default.
• W1973744346 cites W2004868309 @default.
• W1973744346 cites W2006090981 @default.
• W1973744346 cites W2006129103 @default.
• W1973744346 cites W2008303351 @default.
• W1973744346 cites W2017063149 @default.
• W1973744346 cites W2017658177 @default.
• W1973744346 cites W2028473674 @default.
• W1973744346 cites W2028484749 @default.
• W1973744346 cites W2031932032 @default.
• W1973744346 cites W2034176125 @default.
• W1973744346 cites W2040855917 @default.
• W1973744346 cites W2046876459 @default.
• W1973744346 cites W2050224291 @default.
• W1973744346 cites W2052976216 @default.
• W1973744346 cites W2057073947 @default.
• W1973744346 cites W2057894541 @default.
• W1973744346 cites W2058336277 @default.
• W1973744346 cites W2062772531 @default.
• W1973744346 cites W2069267101 @default.
• W1973744346 cites W2074989782 @default.
• W1973744346 cites W2082789276 @default.
• W1973744346 cites W2085011026 @default.
• W1973744346 cites W2088542797 @default.
• W1973744346 cites W2089338912 @default.
• W1973744346 cites W2090469073 @default.
• W1973744346 cites W2093475470 @default.
• W1973744346 cites W2099975374 @default.
• W1973744346 cites W2101625991 @default.
• W1973744346 cites W2102230285 @default.
• W1973744346 cites W2102375930 @default.
• W1973744346 cites W2105157304 @default.
• W1973744346 cites W2105752803 @default.
• W1973744346 cites W2107133702 @default.
• W1973744346 cites W2107320528 @default.
• W1973744346 cites W2116242834 @default.
• W1973744346 cites W2117208932 @default.
• W1973744346 cites W2118516008 @default.
• W1973744346 cites W2120267429 @default.
• W1973744346 cites W2125530007 @default.
• W1973744346 cites W2128420761 @default.
• W1973744346 cites W2131573781 @default.
• W1973744346 cites W2133464980 @default.
• W1973744346 cites W2137288855 @default.
• W1973744346 cites W2139593954 @default.
• W1973744346 cites W2149826895 @default.
• W1973744346 cites W2162082796 @default.
• W1973744346 cites W2167689408 @default.
• W1973744346 cites W2168230176 @default.
• W1973744346 cites W2169479628 @default.
• W1973744346 cites W2176431604 @default.
• W1973744346 cites W2398410876 @default.
• W1973744346 doi "https://doi.org/10.1085/jgp.200910324" @default.
• W1973744346 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2812505" @default.
• W1973744346 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20100894" @default.
• W1973744346 hasPublicationYear "2010" @default.
• W1973744346 type Work @default.
• W1973744346 sameAs 1973744346 @default.
• W1973744346 citedByCount "7" @default.
• W1973744346 countsByYear W19737443462012 @default.
• W1973744346 countsByYear W19737443462014 @default.
• W1973744346 countsByYear W19737443462015 @default.
• W1973744346 crossrefType "journal-article" @default.
• W1973744346 hasAuthorship W1973744346A5041904342 @default.
• W1973744346 hasAuthorship W1973744346A5084845875 @default.
• W1973744346 hasBestOaLocation W19737443461 @default.
• W1973744346 hasConcept C121332964 @default.
• W1973744346 hasConcept C12554922 @default.
• W1973744346 hasConcept C145148216 @default.
• W1973744346 hasConcept C153461711 @default.
• W1973744346 hasConcept C159467904 @default.
• W1973744346 hasConcept C165801399 @default.
• W1973744346 hasConcept C170493617 @default.
• W1973744346 hasConcept C178790620 @default.
• W1973744346 hasConcept C185592680 @default.
• W1973744346 hasConcept C37088560 @default.
• W1973744346 hasConcept C4141045 @default.
• W1973744346 hasConcept C50254741 @default.
• W1973744346 hasConcept C519063684 @default.
• W1973744346 hasConcept C55493867 @default.
• W1973744346 hasConcept C60799052 @default.
• W1973744346 hasConcept C62520636 @default.
• W1973744346 hasConcept C86803240 @default.

• next