FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1973749578> ?p ?o ?g. }

• W1973749578 endingPage "1151" @default.
• W1973749578 startingPage "1145" @default.
• W1973749578 abstract "To investigate whether agonist anti-platelet-derived growth factor receptor alpha (anti-PDGFRalpha) antibodies are present in the serum of patients with systemic sclerosis (SSc; scleroderma).Sera were obtained from healthy subjects and scleroderma patients. An electrochemiluminescence binding assay was performed for detection of serum autoantibodies to PDGFRalpha, PDGFRbeta, epidermal growth factor receptor (EGFR), and colony-stimulating factor receptor 1 (CSFR1). Serum immunoglobulin was purified by protein A/G chromatography. To assess Ig agonist activity, PDGFRalpha-expressing cells were incubated with pure Ig and the level of receptor phosphorylation determined in an enzyme-linked immunoassay, as well as by Western blotting. Ig agonist activity was also assessed in a mitogenic assay and by MAP kinase activation in a PDGFRalpha-expressing cell line.Sera from 34.3% of the healthy subjects and 32.7% of the SSc patients contained detectable autoantibodies to PDGFRalpha and PDGFRbeta, but not EGFR or CSFR1. Purified Ig from these sera was shown to retain PDGFR binding activity and, at 200-1,000 microg/ml, exhibited no agonist activity in a cell-based PDGFRalpha phosphorylation assay and did not stimulate a mitogenic response or MAP kinase activation in a PDGFRalpha-expressing cell line. Two purified Ig samples that were unable to bind PDGFRalpha did exhibit binding activity to a nonglycosylated form of PDGFRalpha.Although approximately one-third of sera from scleroderma patients contained detectable autoantibodies to PDGFR, these antibodies were not specific to scleroderma, since they were also detected in a similar percentage of samples from normal subjects. PDGFRalpha agonist activity was not demonstrated when purified Ig from these sera was tested in cell-based assays." @default.
• W1973749578 created "2016-06-24" @default.
• W1973749578 creator A5000987410 @default.
• W1973749578 creator A5008093033 @default.
• W1973749578 creator A5009211703 @default.
• W1973749578 creator A5012409867 @default.
• W1973749578 creator A5053203692 @default.
• W1973749578 creator A5068528030 @default.
• W1973749578 creator A5080990622 @default.
• W1973749578 creator A5082284314 @default.
• W1973749578 date "2009-03-30" @default.
• W1973749578 modified "2023-10-09" @default.
• W1973749578 title "Lack of detection of agonist activity by antibodies to platelet-derived growth factor receptor α in a subset of normal and systemic sclerosis patient sera" @default.
• W1973749578 cites W1924707321 @default.
• W1973749578 cites W2002999999 @default.
• W1973749578 cites W2003940493 @default.
• W1973749578 cites W2028921539 @default.
• W1973749578 cites W2051033942 @default.
• W1973749578 cites W2077627992 @default.
• W1973749578 cites W2079991520 @default.
• W1973749578 cites W2081741824 @default.
• W1973749578 cites W2160630948 @default.
• W1973749578 cites W2161021883 @default.
• W1973749578 cites W2167672869 @default.
• W1973749578 cites W2169865627 @default.
• W1973749578 doi "https://doi.org/10.1002/art.24365" @default.
• W1973749578 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19333919" @default.
• W1973749578 hasPublicationYear "2009" @default.
• W1973749578 type Work @default.
• W1973749578 sameAs 1973749578 @default.
• W1973749578 citedByCount "73" @default.
• W1973749578 countsByYear W19737495782012 @default.
• W1973749578 countsByYear W19737495782013 @default.
• W1973749578 countsByYear W19737495782014 @default.
• W1973749578 countsByYear W19737495782015 @default.
• W1973749578 countsByYear W19737495782016 @default.
• W1973749578 countsByYear W19737495782017 @default.
• W1973749578 countsByYear W19737495782018 @default.
• W1973749578 countsByYear W19737495782019 @default.
• W1973749578 countsByYear W19737495782020 @default.
• W1973749578 countsByYear W19737495782021 @default.
• W1973749578 countsByYear W19737495782022 @default.
• W1973749578 countsByYear W19737495782023 @default.
• W1973749578 crossrefType "journal-article" @default.
• W1973749578 hasAuthorship W1973749578A5000987410 @default.
• W1973749578 hasAuthorship W1973749578A5008093033 @default.
• W1973749578 hasAuthorship W1973749578A5009211703 @default.
• W1973749578 hasAuthorship W1973749578A5012409867 @default.
• W1973749578 hasAuthorship W1973749578A5053203692 @default.
• W1973749578 hasAuthorship W1973749578A5068528030 @default.
• W1973749578 hasAuthorship W1973749578A5080990622 @default.
• W1973749578 hasAuthorship W1973749578A5082284314 @default.
• W1973749578 hasConcept C11960822 @default.
• W1973749578 hasConcept C126322002 @default.
• W1973749578 hasConcept C134018914 @default.
• W1973749578 hasConcept C153911025 @default.
• W1973749578 hasConcept C159654299 @default.
• W1973749578 hasConcept C163764329 @default.
• W1973749578 hasConcept C170493617 @default.
• W1973749578 hasConcept C180361614 @default.
• W1973749578 hasConcept C184235292 @default.
• W1973749578 hasConcept C203014093 @default.
• W1973749578 hasConcept C2775960820 @default.
• W1973749578 hasConcept C2776362946 @default.
• W1973749578 hasConcept C2778938600 @default.
• W1973749578 hasConcept C55493867 @default.
• W1973749578 hasConcept C71924100 @default.
• W1973749578 hasConcept C86803240 @default.
• W1973749578 hasConceptScore W1973749578C11960822 @default.
• W1973749578 hasConceptScore W1973749578C126322002 @default.
• W1973749578 hasConceptScore W1973749578C134018914 @default.
• W1973749578 hasConceptScore W1973749578C153911025 @default.
• W1973749578 hasConceptScore W1973749578C159654299 @default.
• W1973749578 hasConceptScore W1973749578C163764329 @default.
• W1973749578 hasConceptScore W1973749578C170493617 @default.
• W1973749578 hasConceptScore W1973749578C180361614 @default.
• W1973749578 hasConceptScore W1973749578C184235292 @default.
• W1973749578 hasConceptScore W1973749578C203014093 @default.
• W1973749578 hasConceptScore W1973749578C2775960820 @default.
• W1973749578 hasConceptScore W1973749578C2776362946 @default.
• W1973749578 hasConceptScore W1973749578C2778938600 @default.
• W1973749578 hasConceptScore W1973749578C55493867 @default.
• W1973749578 hasConceptScore W1973749578C71924100 @default.
• W1973749578 hasConceptScore W1973749578C86803240 @default.
• W1973749578 hasIssue "4" @default.
• W1973749578 hasLocation W19737495781 @default.
• W1973749578 hasLocation W19737495782 @default.
• W1973749578 hasOpenAccess W1973749578 @default.
• W1973749578 hasPrimaryLocation W19737495781 @default.
• W1973749578 hasRelatedWork W2050268899 @default.
• W1973749578 hasRelatedWork W2070276514 @default.
• W1973749578 hasRelatedWork W2076581167 @default.
• W1973749578 hasRelatedWork W2078751457 @default.
• W1973749578 hasRelatedWork W2087890016 @default.
• W1973749578 hasRelatedWork W2406683296 @default.
• W1973749578 hasRelatedWork W2423281006 @default.
• W1973749578 hasRelatedWork W368310162 @default.
• W1973749578 hasRelatedWork W4283700508 @default.

• next