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• W1973751608 abstract "Three new terpene metabolites (1–3) were isolated from the marine sponge Clathria gombawuiensis collected from Korean waters. On the basis of the results of combined spectroscopic analyses, the structures of phorone B (1) and ansellone C (2) were determined to be the sesterterpenes of the phorone and ansellone classes, respectively, whereas the saponin gombaside A (3) was a nortriterpene sodium O-sulfonato-glucuronide of the rare 4,4,14-trimethylpregnane class. The absolute configuration of the glucuronate of 3 was assigned by an application of the phenylglycine methyl ester (PGME) method. The new compounds exhibited moderate cytotoxicity against A549 and K562 cell lines, and compound 3 showed antibacterial activity. The cytotoxicity of 1 may be related to the presence of a free phenolic −OH group, as the corresponding O-methoxy derivative 4 is inactive." @default.
• W1973751608 created "2016-06-24" @default.
• W1973751608 creator A5000424971 @default.
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• W1973751608 date "2015-01-29" @default.
• W1973751608 modified "2023-10-16" @default.
• W1973751608 title "Additional Sesterterpenes and a Nortriterpene Saponin from the Sponge <i>Clathria gombawuiensis</i>" @default.
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• W1973751608 doi "https://doi.org/10.1021/np500753q" @default.
• W1973751608 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25634623" @default.
• W1973751608 hasPublicationYear "2015" @default.
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