Matches in SemOpenAlex for { <https://semopenalex.org/work/W1973756556> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W1973756556 endingPage "874" @default.
- W1973756556 startingPage "867" @default.
- W1973756556 abstract "Proteins recognizing DNA damaged by the chemical carcinogen N-acetoxy-acetylaminofluorene (AAAF) were analyzed in nuclear extracts from rat tissues, using a 36 bp oligonucleotide as a substrate and electrophoretic mobility shift and Southwestern blot assays. One major damage-recognizing protein was detected, whose amount was estimated as at least 10(5) copies per cell. Levels of this protein were similar in extracts from brain, kidney and liver, but much lower in extracts from testis. The affinity of the detected protein for DNA damaged by AAAF was about 70-fold higher than for undamaged DNA. DNA damaged by cis-diamminedichloroplatinum (cis-DDP), benzo(a)pyrene diolepoxide (BPDE) or UV-radiation also bound this protein with an increased affinity, the former more strongly and the latter two more weakly as compared to AAAF-damaged DNA. The detected AAAF/DDP-damaged-DNA-binding (AAAF/DDP-DDB) protein had a molecular mass of about 25 kDa and was distinct from histone H1 or HMGB proteins, which are known to have a high affinity for cis-DDP-damaged DNA. The level of this damage-recognizing protein was not affected in rats treated with the carcinogen 2-acetylaminofluorene. The activity of an AAAF/DDP-DDB protein could also be detected in extracts from mouse liver cells but not from the Hep2G human hepatocellular carcinoma." @default.
- W1973756556 created "2016-06-24" @default.
- W1973756556 creator A5037979882 @default.
- W1973756556 creator A5050285030 @default.
- W1973756556 date "2005-06-06" @default.
- W1973756556 modified "2023-10-18" @default.
- W1973756556 title "Characterization of a novel protein that specifically binds to DNA modified by N-acetoxy-acetylaminofluorene and cis-diamminedichloroplatinum." @default.
- W1973756556 cites W1017863778 @default.
- W1973756556 cites W1497324858 @default.
- W1973756556 cites W1500473397 @default.
- W1973756556 cites W1506170911 @default.
- W1973756556 cites W1521081650 @default.
- W1973756556 cites W1559438128 @default.
- W1973756556 cites W1589402586 @default.
- W1973756556 cites W1971380388 @default.
- W1973756556 cites W1991214623 @default.
- W1973756556 cites W1994875540 @default.
- W1973756556 cites W2002071825 @default.
- W1973756556 cites W2002294822 @default.
- W1973756556 cites W2005943555 @default.
- W1973756556 cites W2010121081 @default.
- W1973756556 cites W2014799848 @default.
- W1973756556 cites W2019759754 @default.
- W1973756556 cites W2022959425 @default.
- W1973756556 cites W2024938137 @default.
- W1973756556 cites W2041763793 @default.
- W1973756556 cites W2041791051 @default.
- W1973756556 cites W2051031816 @default.
- W1973756556 cites W2073113061 @default.
- W1973756556 cites W2083743027 @default.
- W1973756556 cites W2088793065 @default.
- W1973756556 cites W2090995659 @default.
- W1973756556 cites W2124227044 @default.
- W1973756556 cites W2127397039 @default.
- W1973756556 doi "https://doi.org/10.18388/abp.2005_3400" @default.
- W1973756556 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15940347" @default.
- W1973756556 hasPublicationYear "2005" @default.
- W1973756556 type Work @default.
- W1973756556 sameAs 1973756556 @default.
- W1973756556 citedByCount "4" @default.
- W1973756556 crossrefType "journal-article" @default.
- W1973756556 hasAuthorship W1973756556A5037979882 @default.
- W1973756556 hasAuthorship W1973756556A5050285030 @default.
- W1973756556 hasBestOaLocation W19737565561 @default.
- W1973756556 hasConcept C104317684 @default.
- W1973756556 hasConcept C114246631 @default.
- W1973756556 hasConcept C116084860 @default.
- W1973756556 hasConcept C129312508 @default.
- W1973756556 hasConcept C143425029 @default.
- W1973756556 hasConcept C153911025 @default.
- W1973756556 hasConcept C181199279 @default.
- W1973756556 hasConcept C185592680 @default.
- W1973756556 hasConcept C2777538855 @default.
- W1973756556 hasConcept C2779838395 @default.
- W1973756556 hasConcept C29512474 @default.
- W1973756556 hasConcept C552990157 @default.
- W1973756556 hasConcept C55493867 @default.
- W1973756556 hasConcept C86339819 @default.
- W1973756556 hasConcept C86803240 @default.
- W1973756556 hasConcept C87644729 @default.
- W1973756556 hasConceptScore W1973756556C104317684 @default.
- W1973756556 hasConceptScore W1973756556C114246631 @default.
- W1973756556 hasConceptScore W1973756556C116084860 @default.
- W1973756556 hasConceptScore W1973756556C129312508 @default.
- W1973756556 hasConceptScore W1973756556C143425029 @default.
- W1973756556 hasConceptScore W1973756556C153911025 @default.
- W1973756556 hasConceptScore W1973756556C181199279 @default.
- W1973756556 hasConceptScore W1973756556C185592680 @default.
- W1973756556 hasConceptScore W1973756556C2777538855 @default.
- W1973756556 hasConceptScore W1973756556C2779838395 @default.
- W1973756556 hasConceptScore W1973756556C29512474 @default.
- W1973756556 hasConceptScore W1973756556C552990157 @default.
- W1973756556 hasConceptScore W1973756556C55493867 @default.
- W1973756556 hasConceptScore W1973756556C86339819 @default.
- W1973756556 hasConceptScore W1973756556C86803240 @default.
- W1973756556 hasConceptScore W1973756556C87644729 @default.
- W1973756556 hasIssue "4" @default.
- W1973756556 hasLocation W19737565561 @default.
- W1973756556 hasLocation W19737565562 @default.
- W1973756556 hasOpenAccess W1973756556 @default.
- W1973756556 hasPrimaryLocation W19737565561 @default.
- W1973756556 hasRelatedWork W1527621726 @default.
- W1973756556 hasRelatedWork W1994620628 @default.
- W1973756556 hasRelatedWork W2006101991 @default.
- W1973756556 hasRelatedWork W2020271255 @default.
- W1973756556 hasRelatedWork W2029297666 @default.
- W1973756556 hasRelatedWork W2040399764 @default.
- W1973756556 hasRelatedWork W2062781774 @default.
- W1973756556 hasRelatedWork W2070414536 @default.
- W1973756556 hasRelatedWork W2417706563 @default.
- W1973756556 hasRelatedWork W2418044896 @default.
- W1973756556 hasVolume "52" @default.
- W1973756556 isParatext "false" @default.
- W1973756556 isRetracted "false" @default.
- W1973756556 magId "1973756556" @default.
- W1973756556 workType "article" @default.