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- W1973757906 abstract "The effects of the 5HT1A receptor agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) on medullary 5-hydroxy-tryptamine (5-HT) neuronal firing and inferior cardiac sympathetic nerve activity were simultaneously determined in baroreceptor-denervated cats. 5-HT neuronal firing was inhibited by 50% at a 1 microgram/kg i.v. dose of 8-OH-DPAT in the baroreceptor-denervated animal. Unit firing was completely inhibited by a 3 microgram/kg dose. In contrast, 8-OH-DPAT inhibited inferior cardiac nerve activity between 10 and 100 micrograms/kg i.v. A similar relationship between the 8-OH-DPAT-induced inhibition of 5-HT unit activity and sympathetic nerve activity was observed in sham-operated control animals. These data suggest that the sympatholytic effects of 8-OH-DPAT cannot be explained on the basis of an autoreceptor effect of the drug." @default.
- W1973757906 created "2016-06-24" @default.
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- W1973757906 date "1991-08-01" @default.
- W1973757906 modified "2023-09-27" @default.
- W1973757906 title "The effects of 8-OH-DPAT on medulllary 5-HT neurons and sympathetic activity in baroreceptor-denervated animals" @default.
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- W1973757906 doi "https://doi.org/10.1016/0014-2999(91)90596-i" @default.
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