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- W1973758148 abstract "We have investigated the endothelin receptor subtypes mediating contraction in isolated preparations of human saphenous vein. Endothelin-1 (EC50: 17.8 nM), endothelin-3 (EC50: 82.3 nM) and the endothelin ETB receptor-selective agonists, [Ala1,3,11,15]endothelin-1 (EC50: 63 nM) and sarafotoxin S6c (EC50: 0.75 nM) all produced concentration-dependent contractions of human saphenous vein, although [Ala1,3,11,15]endothelin-1 and sarafotoxin S6c only produced a contraction in ∼50% of the preparations tested. The endothelin ETA receptor antagonist, BQ123 (D-Val,Leu,D-Trp,D-Asp,Pro; 10 μM), antagonized endothelin-1-induced contractions with an estimated potency (pKB ∼ 6.0) which was an order of magnitude lower than reported previously for non-human isolated vascular tissues from other species (pA2 values ∼ 7.0). These data suggest that both endothelin ETA and endothelin ETB receptors can mediate vascular smooth muscle contraction in human saphenous vein." @default.
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- W1973758148 date "1994-05-01" @default.
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- W1973758148 title "Human saphenous vein contains both endothelin ETA and ETB contractile receptors" @default.
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- W1973758148 doi "https://doi.org/10.1016/0014-2999(94)90144-9" @default.
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