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- W1973770159 abstract "Although some allografts bearing major and minor transplantation antigens can survive after the cessation of immunosuppression with cyclosporin-A (Cy-A), nerve allografts do not. In an attempt to induce immunological unresponsiveness to nerve allografts, we used grafts containing only minor transplantation antigens and varied the duration of Cy-A therapy from 2 to 12 weeks. Our results demonstrated that nerve allografts survived in rats during Cy-A therapy, but when the drug administration ceased, the allografts were rejected. Other factors besides the degree of histoincompatibility and duration of Cy-A treatment must be involved in determining whether or not unresponsiveness develops to allografts after Cy-A withdrawal. We conclude that nerve allograft immunosuppression generated by Cy-A requires regular administration of the drug." @default.
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- W1973770159 date "1984-03-01" @default.
- W1973770159 modified "2023-10-17" @default.
- W1973770159 title "Failure of cyclosporin-A to induce immunological unresponsiveness to nerve allografts" @default.
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- W1973770159 doi "https://doi.org/10.1016/0014-4886(84)90134-1" @default.
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