FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1973770168> ?p ?o ?g. }

• W1973770168 endingPage "724" @default.
• W1973770168 startingPage "717" @default.
• W1973770168 abstract "Human adipose stromal cells (ASCs) reside within the stromal-vascular fraction (SVF) in fat tissue, can be readily isolated, and include stem-like cells that may be useful for therapy. An important consideration for clinical application and functional studies of stem/progenitor cells is their capacity to maintain chromosome stability in culture. In this study, cultured ASC populations and ASC clones were evaluated at intervals for maintenance of chromosome stability. Uncultured SVF (uSVF) cells were included for comparison. G-banded chromosome analysis demonstrated that ASCs are diploid and have a normal karyotype. However since only ~20 cells are examined, low levels of chromosome instability would not be detected. To increase detection sensitivity, fluorescence in situ hybridization was employed, to permit chromosome enumeration in larger numbers of interphase cells. Seven cultured ASC populations, two ASC clones and four uSVF samples were examined. Chromosome X and 17 probes identified diploid, tetraploid, and aneuploid interphase cells. Both cultured ASC populations [up to ~35 Population Doublings (PDs)] and uSVF cells exhibited a similar level of diploidy (97.8% n = 6,355 and 98.83% n = 1,197, respectively) and numerical abnormalities, suggesting that cultured ASCs are genomically stable and supporting their suitability for transplantation applications. In comparison, cultured primary human chorionic villus cells exhibited marked genomic instability resulting in an 11.6% tetraploidy rate after 8–10 PD. Thus effects of culture on genomic stability may be cell type dependent and should be tested by appropriately scaled interphase fluorescence in situ hybridization analysis in any ex vivo expanded cell population destined for transplantation." @default.
• W1973770168 created "2016-06-24" @default.
• W1973770168 creator A5014006995 @default.
• W1973770168 creator A5015070707 @default.
• W1973770168 creator A5018368124 @default.
• W1973770168 creator A5018512578 @default.
• W1973770168 creator A5031736885 @default.
• W1973770168 creator A5036192979 @default.
• W1973770168 creator A5037621889 @default.
• W1973770168 creator A5038864277 @default.
• W1973770168 creator A5081939392 @default.
• W1973770168 creator A5086286601 @default.
• W1973770168 creator A5086992735 @default.
• W1973770168 creator A5089543020 @default.
• W1973770168 date "2009-06-01" @default.
• W1973770168 modified "2023-09-25" @default.
• W1973770168 title "Interphase FISH Demonstrates that Human Adipose Stromal Cells Maintain a High Level of Genomic Stability in Long-Term Culture" @default.
• W1973770168 cites W1525110505 @default.
• W1973770168 cites W1974812650 @default.
• W1973770168 cites W1978969115 @default.
• W1973770168 cites W1979868276 @default.
• W1973770168 cites W1981987414 @default.
• W1973770168 cites W1991177217 @default.
• W1973770168 cites W2006549340 @default.
• W1973770168 cites W2017043267 @default.
• W1973770168 cites W2018671779 @default.
• W1973770168 cites W2020684993 @default.
• W1973770168 cites W2036532745 @default.
• W1973770168 cites W2053704719 @default.
• W1973770168 cites W2087502608 @default.
• W1973770168 cites W2093413490 @default.
• W1973770168 cites W2098892229 @default.
• W1973770168 cites W2106193879 @default.
• W1973770168 cites W2112899131 @default.
• W1973770168 cites W2113415925 @default.
• W1973770168 cites W2118458879 @default.
• W1973770168 cites W2138811791 @default.
• W1973770168 cites W2140057768 @default.
• W1973770168 cites W2145524503 @default.
• W1973770168 cites W2166661372 @default.
• W1973770168 doi "https://doi.org/10.1089/scd.2008.0255" @default.
• W1973770168 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3135207" @default.
• W1973770168 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18754715" @default.
• W1973770168 hasPublicationYear "2009" @default.
• W1973770168 type Work @default.
• W1973770168 sameAs 1973770168 @default.
• W1973770168 citedByCount "49" @default.
• W1973770168 countsByYear W19737701682012 @default.
• W1973770168 countsByYear W19737701682013 @default.
• W1973770168 countsByYear W19737701682014 @default.
• W1973770168 countsByYear W19737701682015 @default.
• W1973770168 countsByYear W19737701682017 @default.
• W1973770168 countsByYear W19737701682019 @default.
• W1973770168 countsByYear W19737701682020 @default.
• W1973770168 countsByYear W19737701682021 @default.
• W1973770168 countsByYear W19737701682022 @default.
• W1973770168 crossrefType "journal-article" @default.
• W1973770168 hasAuthorship W1973770168A5014006995 @default.
• W1973770168 hasAuthorship W1973770168A5015070707 @default.
• W1973770168 hasAuthorship W1973770168A5018368124 @default.
• W1973770168 hasAuthorship W1973770168A5018512578 @default.
• W1973770168 hasAuthorship W1973770168A5031736885 @default.
• W1973770168 hasAuthorship W1973770168A5036192979 @default.
• W1973770168 hasAuthorship W1973770168A5037621889 @default.
• W1973770168 hasAuthorship W1973770168A5038864277 @default.
• W1973770168 hasAuthorship W1973770168A5081939392 @default.
• W1973770168 hasAuthorship W1973770168A5086286601 @default.
• W1973770168 hasAuthorship W1973770168A5086992735 @default.
• W1973770168 hasAuthorship W1973770168A5089543020 @default.
• W1973770168 hasBestOaLocation W19737701682 @default.
• W1973770168 hasConcept C104317684 @default.
• W1973770168 hasConcept C143191323 @default.
• W1973770168 hasConcept C144024400 @default.
• W1973770168 hasConcept C149923435 @default.
• W1973770168 hasConcept C153911025 @default.
• W1973770168 hasConcept C16930146 @default.
• W1973770168 hasConcept C201750760 @default.
• W1973770168 hasConcept C2777542201 @default.
• W1973770168 hasConcept C28328180 @default.
• W1973770168 hasConcept C2908647359 @default.
• W1973770168 hasConcept C29452124 @default.
• W1973770168 hasConcept C30481170 @default.
• W1973770168 hasConcept C502942594 @default.
• W1973770168 hasConcept C53226629 @default.
• W1973770168 hasConcept C54355233 @default.
• W1973770168 hasConcept C86803240 @default.
• W1973770168 hasConceptScore W1973770168C104317684 @default.
• W1973770168 hasConceptScore W1973770168C143191323 @default.
• W1973770168 hasConceptScore W1973770168C144024400 @default.
• W1973770168 hasConceptScore W1973770168C149923435 @default.
• W1973770168 hasConceptScore W1973770168C153911025 @default.
• W1973770168 hasConceptScore W1973770168C16930146 @default.
• W1973770168 hasConceptScore W1973770168C201750760 @default.
• W1973770168 hasConceptScore W1973770168C2777542201 @default.
• W1973770168 hasConceptScore W1973770168C28328180 @default.
• W1973770168 hasConceptScore W1973770168C2908647359 @default.
• W1973770168 hasConceptScore W1973770168C29452124 @default.
• W1973770168 hasConceptScore W1973770168C30481170 @default.

• next