Matches in SemOpenAlex for { <https://semopenalex.org/work/W1973780743> ?p ?o ?g. }
Showing items 1 to 87 of
87
with 100 items per page.
- W1973780743 abstract "Dendritic iron porphyrins were synthesized as functional mimics of globular electron-transfer heme proteins. The cascade molecules 1 · Zn−3 Zn of first to third generation were obtained starting from the (meso-diarylporphyrin) zinc 6 · Zn which contains four carboxylate arms for attachment of the poly(ether-amide) dendritic branches by peptide-coupling methodology (Scheme 1). Generation 3 compound 3 · Zn with 108 methyl-carboxylate end groups has a molecular weight of 19054. D, and computer modeling suggests that its structure is globular and densely-packed, measuring ca. 4 nm in diameter and, therefore, similar in dimensions to the electron-transfer protein cytochrome-c. Starting from the generation 1 poly(carboxylic acid) 11 · Zn and the generation 2 analog 12 · Zn the dendritic ZnII porphyrins 4 · Zn and 5 · Zn, respectively, were obtained by esterification with triethyleneglycol monomethyl ether (Schemes 3 and 4). Demetallation followed by insertion of FeII and in situ oxidation afforded the water-soluble dendritic iron porphyrins 4 FeCl and 5 FeCl. The electrochemical behavior of esters 1 · Zn−3 · Zn in organic solvents changed smoothly with increasing dendritic generation (Table 1). Progressing from 1 · Zn to 3 · Zn in THF, the first porphyrin-centered oxidation and reduction potentials become more negative by 320 and 210mV, respectively. These changes were attributed to strong microenvironmental effects imposed on the electroactive core by the densely packed dendritic surroundings. The electrochemical properties of 4 · FeCl and 5 · FeCl were investigated by cyclic voltammetry in both CH2Cl2 and H2O (Tables 2 and 3). Progressing from 4 · FeCl to 5 · FeCl in CH2Cl2, the redox potential of the biologically relevant FeIII/FeII couple remained virtually unchanged, whereas in aqueous solution, 5 FeCl exhibited a potential 420 mV more positive than did 4 FeCl. The large difference between these potentials in H2O was attributed to differences in solvation of the core electrophore. Whereas the relatively open dendritic branches in 4 · Fecl do not impede access of bulk solvent to the central core, the densely packed dendritic superstructure of 5 · FeCl significantly reduces contact between the heme and external solvent. As a result, the more charged FeIII state is destabilized relative to FeII, and the redox potential is strongly shifted to a more positive value." @default.
- W1973780743 created "2016-06-24" @default.
- W1973780743 creator A5003743501 @default.
- W1973780743 creator A5010903556 @default.
- W1973780743 creator A5023198463 @default.
- W1973780743 creator A5029745054 @default.
- W1973780743 creator A5061843020 @default.
- W1973780743 creator A5075367583 @default.
- W1973780743 creator A5084188808 @default.
- W1973780743 date "2010-08-02" @default.
- W1973780743 modified "2023-09-27" @default.
- W1973780743 title "ChemInform Abstract: Dendrimers with Porphyrin Cores: Synthetic Models for Globular Heme Proteins" @default.
- W1973780743 cites W2953261161 @default.
- W1973780743 doi "https://doi.org/10.1002/chin.199748221" @default.
- W1973780743 hasPublicationYear "2010" @default.
- W1973780743 type Work @default.
- W1973780743 sameAs 1973780743 @default.
- W1973780743 citedByCount "0" @default.
- W1973780743 crossrefType "journal-article" @default.
- W1973780743 hasAuthorship W1973780743A5003743501 @default.
- W1973780743 hasAuthorship W1973780743A5010903556 @default.
- W1973780743 hasAuthorship W1973780743A5023198463 @default.
- W1973780743 hasAuthorship W1973780743A5029745054 @default.
- W1973780743 hasAuthorship W1973780743A5061843020 @default.
- W1973780743 hasAuthorship W1973780743A5075367583 @default.
- W1973780743 hasAuthorship W1973780743A5084188808 @default.
- W1973780743 hasConcept C123669783 @default.
- W1973780743 hasConcept C147789679 @default.
- W1973780743 hasConcept C17525397 @default.
- W1973780743 hasConcept C178790620 @default.
- W1973780743 hasConcept C181199279 @default.
- W1973780743 hasConcept C185592680 @default.
- W1973780743 hasConcept C188027245 @default.
- W1973780743 hasConcept C20705724 @default.
- W1973780743 hasConcept C2776217839 @default.
- W1973780743 hasConcept C2777869211 @default.
- W1973780743 hasConcept C2778074193 @default.
- W1973780743 hasConcept C2779480358 @default.
- W1973780743 hasConcept C2780407432 @default.
- W1973780743 hasConcept C52859227 @default.
- W1973780743 hasConcept C535196362 @default.
- W1973780743 hasConcept C55637122 @default.
- W1973780743 hasConcept C71240020 @default.
- W1973780743 hasConceptScore W1973780743C123669783 @default.
- W1973780743 hasConceptScore W1973780743C147789679 @default.
- W1973780743 hasConceptScore W1973780743C17525397 @default.
- W1973780743 hasConceptScore W1973780743C178790620 @default.
- W1973780743 hasConceptScore W1973780743C181199279 @default.
- W1973780743 hasConceptScore W1973780743C185592680 @default.
- W1973780743 hasConceptScore W1973780743C188027245 @default.
- W1973780743 hasConceptScore W1973780743C20705724 @default.
- W1973780743 hasConceptScore W1973780743C2776217839 @default.
- W1973780743 hasConceptScore W1973780743C2777869211 @default.
- W1973780743 hasConceptScore W1973780743C2778074193 @default.
- W1973780743 hasConceptScore W1973780743C2779480358 @default.
- W1973780743 hasConceptScore W1973780743C2780407432 @default.
- W1973780743 hasConceptScore W1973780743C52859227 @default.
- W1973780743 hasConceptScore W1973780743C535196362 @default.
- W1973780743 hasConceptScore W1973780743C55637122 @default.
- W1973780743 hasConceptScore W1973780743C71240020 @default.
- W1973780743 hasLocation W19737807431 @default.
- W1973780743 hasOpenAccess W1973780743 @default.
- W1973780743 hasPrimaryLocation W19737807431 @default.
- W1973780743 hasRelatedWork W1579404782 @default.
- W1973780743 hasRelatedWork W1968623016 @default.
- W1973780743 hasRelatedWork W1991368751 @default.
- W1973780743 hasRelatedWork W2003513769 @default.
- W1973780743 hasRelatedWork W2007020059 @default.
- W1973780743 hasRelatedWork W2016907402 @default.
- W1973780743 hasRelatedWork W2030144139 @default.
- W1973780743 hasRelatedWork W2041336045 @default.
- W1973780743 hasRelatedWork W2048954490 @default.
- W1973780743 hasRelatedWork W2049232607 @default.
- W1973780743 hasRelatedWork W2059325322 @default.
- W1973780743 hasRelatedWork W2061392795 @default.
- W1973780743 hasRelatedWork W2064523470 @default.
- W1973780743 hasRelatedWork W2082407993 @default.
- W1973780743 hasRelatedWork W2099359187 @default.
- W1973780743 hasRelatedWork W2620906046 @default.
- W1973780743 hasRelatedWork W2924019060 @default.
- W1973780743 hasRelatedWork W2946855080 @default.
- W1973780743 hasRelatedWork W2953261161 @default.
- W1973780743 hasRelatedWork W2996283556 @default.
- W1973780743 isParatext "false" @default.
- W1973780743 isRetracted "false" @default.
- W1973780743 magId "1973780743" @default.
- W1973780743 workType "article" @default.