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- W1973787788 abstract "Benzpyrene hydroxylase activity in human placental tissues was investigated during early gestation (8–16 wk) in order to determine whether cigarette smoking would produce increased hydroxylation capacity at this gestational stage. Particulate subfractions of term placental homogenates from women who smoked cigarettes during pregnancy exhibited relatively high levels of enzymatic activity. At 8–10 wk gestation, however, levels of enzymatic activity in homogenates of human placenta or fetal livers were undetectable regardless of maternal smoking habits. At 11–13 wk gestation, very low levels of hydroxylase activity were observed in placentas of smokers, and slightly higher levels were apparent in smoker placentas at 14–16 wk gestation. Hydroxylating capacity of placental homogenates from nonsmokers was not detected at 8–16 wk gestation. Steroids synthesized by human placental tissues, i.e., β-estradiol, estrone, and progesterone, markedly inhibited the placental-catalyzed hydroxylation of benzpyrene. Cholesterol, dehydroepiandrosterone, testosterone, and androstenedione, which serve as substrates for other placental mixed-function oxidase systems, however, exhibited comparatively minor inhibitory effects. Similar effects of these and other steroids (methyltestosterone and pregenolone) were observed on the placental hydroxylase of 3-methyl-cholanthrene pretreated rats." @default.
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- W1973787788 date "1971-03-01" @default.
- W1973787788 modified "2023-10-15" @default.
- W1973787788 title "Human placental hydroxylation of 3,4-benzpyrene during early gestation and at term" @default.
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- W1973787788 doi "https://doi.org/10.1016/s0041-008x(71)80021-2" @default.
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