FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1973789915> ?p ?o ?g. }

• W1973789915 abstract "Neurons in vivo exhibit irregular firing, and some aspect of their firing pattern such as the degree of firing irregularity does not fluctuate greatly in time for individual neurons, while it differs among neurons [1]. By analyzing spike trains recorded from a variety of cortical areas, it has been revealed that neurons in motor-related cortical areas fire regularly while neurons in visual and prefrontal cortex fire randomly [2]. Here, the firing irregularity is defined as a variability of consecutive interspike intervals, independent of the firing rate. In those studies, the firing rate has been ignored, because it may fluctuate greatly in time depending on external stimuli or behavioral contexts of an animal.Though the neuronal firing rate may fluctuate with external stimuli, this does not necessarily mean that the rate is extrinsic and perfectly controllable; there could be some uncontrollable intrinsic aspect in the firing rate fluctuation. In this contribution, we go contrary to the above-mentioned studies, and attempt to characterize neuronal spike trains solely in terms of the firing rate, ignoring the firing irregularity. The key feature of neuronal spike trains we now pay attention to is dynamic mode of rate fluctuation, such that the rate either fluctuates smoothly in time or changes abruptly between several stationary states.We compare two different models of a fluctuating rate process for their goodness-of-fit with respect to spike trains recorded from single neurons in several cortical areas of rats. The first model is the state space model constructed under the Empirical Bayes method [3,4]. The generative inhomogeneous Poisson process is defined as the conditional distribution of the spike times ti≡t1,t2,...,tn given the rateλ(t), ptiλ(t)= ∏i=1nλ(ti)exp-∫ 0Tλ(t)dt. We give the prior distribution of λ(t) by incorporating the tendency of the rate to be flat, pλ(t)∝exp-β∫ 0Tdλ/dt2dt. The hyperparameter β is selected by the principle of maximizing the marginal likelihood, and then we obtain the maximum a posteriori (MAP) estimate for the rate λ⌢(t). The second alternative model is the Hidden Markov model (HMM) whose hidden states represent different rate states [5-7]. The number of states is selected with a variation Bayes method.In this way, two different estimations of the firing rate are obtained using the continuous state space model and the discrete HMM. We compare them for each spike train obtained from a neuron, and examine whether the continuous or discrete representation of the state transition is more plausible. Then, we examine how the different preferences are distributed in different cortical areas." @default.
• W1973789915 created "2016-06-24" @default.
• W1973789915 creator A5048998219 @default.
• W1973789915 creator A5062966349 @default.
• W1973789915 date "2013-07-01" @default.
• W1973789915 modified "2023-09-24" @default.
• W1973789915 title "Difference in modes of firing rate modulation between cortical areas" @default.
• W1973789915 cites W101662812 @default.
• W1973789915 cites W1978668587 @default.
• W1973789915 cites W2027666633 @default.
• W1973789915 cites W2109843705 @default.
• W1973789915 cites W2164296493 @default.
• W1973789915 cites W2168228198 @default.
• W1973789915 cites W2317175630 @default.
• W1973789915 doi "https://doi.org/10.1186/1471-2202-14-s1-p359" @default.
• W1973789915 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3704806" @default.
• W1973789915 hasPublicationYear "2013" @default.
• W1973789915 type Work @default.
• W1973789915 sameAs 1973789915 @default.
• W1973789915 citedByCount "0" @default.
• W1973789915 crossrefType "journal-article" @default.
• W1973789915 hasAuthorship W1973789915A5048998219 @default.
• W1973789915 hasAuthorship W1973789915A5062966349 @default.
• W1973789915 hasBestOaLocation W19737899151 @default.
• W1973789915 hasConcept C115903868 @default.
• W1973789915 hasConcept C15744967 @default.
• W1973789915 hasConcept C169760540 @default.
• W1973789915 hasConcept C185263204 @default.
• W1973789915 hasConcept C195221683 @default.
• W1973789915 hasConcept C2781390188 @default.
• W1973789915 hasConcept C2909946758 @default.
• W1973789915 hasConcept C2983650178 @default.
• W1973789915 hasConcept C3019868978 @default.
• W1973789915 hasConcept C41008148 @default.
• W1973789915 hasConceptScore W1973789915C115903868 @default.
• W1973789915 hasConceptScore W1973789915C15744967 @default.
• W1973789915 hasConceptScore W1973789915C169760540 @default.
• W1973789915 hasConceptScore W1973789915C185263204 @default.
• W1973789915 hasConceptScore W1973789915C195221683 @default.
• W1973789915 hasConceptScore W1973789915C2781390188 @default.
• W1973789915 hasConceptScore W1973789915C2909946758 @default.
• W1973789915 hasConceptScore W1973789915C2983650178 @default.
• W1973789915 hasConceptScore W1973789915C3019868978 @default.
• W1973789915 hasConceptScore W1973789915C41008148 @default.
• W1973789915 hasLocation W19737899151 @default.
• W1973789915 hasLocation W19737899152 @default.
• W1973789915 hasLocation W19737899153 @default.
• W1973789915 hasOpenAccess W1973789915 @default.
• W1973789915 hasPrimaryLocation W19737899151 @default.
• W1973789915 hasRelatedWork W1681179281 @default.
• W1973789915 hasRelatedWork W1699458429 @default.
• W1973789915 hasRelatedWork W1908250390 @default.
• W1973789915 hasRelatedWork W1972194060 @default.
• W1973789915 hasRelatedWork W1978359496 @default.
• W1973789915 hasRelatedWork W2008461226 @default.
• W1973789915 hasRelatedWork W2027580899 @default.
• W1973789915 hasRelatedWork W2063132105 @default.
• W1973789915 hasRelatedWork W2091082452 @default.
• W1973789915 hasRelatedWork W2113146504 @default.
• W1973789915 hasRelatedWork W2121003524 @default.
• W1973789915 hasRelatedWork W2125502516 @default.
• W1973789915 hasRelatedWork W2146007569 @default.
• W1973789915 hasRelatedWork W2147122301 @default.
• W1973789915 hasRelatedWork W2163447947 @default.
• W1973789915 hasRelatedWork W2163791909 @default.
• W1973789915 hasRelatedWork W2167759766 @default.
• W1973789915 hasRelatedWork W2268123273 @default.
• W1973789915 hasRelatedWork W2895236491 @default.
• W1973789915 hasRelatedWork W57113359 @default.
• W1973789915 isParatext "false" @default.
• W1973789915 isRetracted "false" @default.
• W1973789915 magId "1973789915" @default.
• W1973789915 workType "article" @default.