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- W1973792912 abstract "The objectives of this paper were (1) to review recent research on the actions of vitamin D as a steroid derivative with neuroactive properties and (2) to highlight clinical relevance and need for more research. Our methods included review of research from current journals, Medline, and Cochrane Reviews; theoretical discussion. Scientific research has had a justifiably strong emphasis on how vitamin D affects calcium metabolism and bone. This appears to have eclipsed its fundamental actions on several other important systems, including the central nervous system. Vitamin D as a neuroactive compound, a prohormone, is highly active in regulating cell differentiation, proliferation, and peroxidation in a variety of structures, including the brain. Vitamin D insufficiency is not rare. Historically, focus has been on bone metabolism, which appears to have caused research bias and evidence bias , distorting physiological importance. The central nervous system is increasingly recognized as a target organ for vitamin D via its wide-ranging hormonal effects, including the induction of proteins such as nerve growth factor. We need more research on this important neuroactive substance because it may play a role as a relatively safe and inexpensive pharmaceutical in the prevention and treatment of a number of common neuropsychiatric conditions." @default.
- W1973792912 created "2016-06-24" @default.
- W1973792912 creator A5013672978 @default.
- W1973792912 creator A5024715069 @default.
- W1973792912 creator A5025842687 @default.
- W1973792912 creator A5090404097 @default.
- W1973792912 date "2006-01-01" @default.
- W1973792912 modified "2023-10-18" @default.
- W1973792912 title "Vitamin D as a Neuroactive Substance: Review" @default.
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