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• W1973796123 abstract "Light can kill the photoreceptors of the eye, not only very bright direct sunlight, but more moderate illumination if the light is present continuously. Recent experiments show that rod apoptosis can be triggered by strong and constant activation of transduction, and that death can be prevented if transduction is inhibited even though the eye is illuminated. Vitamin A deficiency and genetically inherited diseases, such as some forms of retinitis pigmentosa and Leber congenital amaurosis, appear to kill like this: transduction is activated at a high rate and continuously, and this causes the rods to die. Why does transduction kill? Our best guess is that continuous activation produces a prolonged lowering of the Ca2+ concentration, which is also thought to kill neurons in tissue culture and during the development of the nervous system. To prevent death in constant light, rods have evolved protective mechanisms including modulation of channels and ion transport to keep the Ca2+ from going too low. Prolonged light exposure also causes migration of transduction proteins from one part of the cell to another and a reversible shortening of the rod outer segments, the part of the cell that contains the pigment rhodopsin. All of these mechanisms are at work in the normal eye to reduce transduction and prevent the Ca2+ concentration from dropping too low for too long a time. That most of us retain our vision our entire lives is a testament to their effectiveness. BioEssays 28: 344–354, 2006. © 2006 Wiley Periodicals, Inc." @default.
• W1973796123 created "2016-06-24" @default.
• W1973796123 creator A5045905817 @default.
• W1973796123 date "2006-01-01" @default.
• W1973796123 modified "2023-10-18" @default.
• W1973796123 title "Why photoreceptors die (and why they don't)" @default.
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• W1973796123 cites W1509709236 @default.
• W1973796123 cites W1524279954 @default.
• W1973796123 cites W1562796888 @default.
• W1973796123 cites W1571044863 @default.
• W1973796123 cites W1587435244 @default.
• W1973796123 cites W1661422265 @default.
• W1973796123 cites W1877154941 @default.
• W1973796123 cites W1882516571 @default.
• W1973796123 cites W1914786390 @default.
• W1973796123 cites W1963653572 @default.
• W1973796123 cites W1964366799 @default.
• W1973796123 cites W1973007853 @default.
• W1973796123 cites W1973875627 @default.
• W1973796123 cites W1977361305 @default.
• W1973796123 cites W1977847223 @default.
• W1973796123 cites W1978131598 @default.
• W1973796123 cites W1978789853 @default.
• W1973796123 cites W1981131515 @default.
• W1973796123 cites W1983421509 @default.
• W1973796123 cites W1983985618 @default.
• W1973796123 cites W1988297454 @default.
• W1973796123 cites W1994152829 @default.
• W1973796123 cites W1999179844 @default.
• W1973796123 cites W2005972504 @default.
• W1973796123 cites W2008653992 @default.
• W1973796123 cites W2008703226 @default.
• W1973796123 cites W2014281451 @default.
• W1973796123 cites W2014764883 @default.
• W1973796123 cites W2015739924 @default.
• W1973796123 cites W2016170285 @default.
• W1973796123 cites W2019362915 @default.
• W1973796123 cites W2022381635 @default.
• W1973796123 cites W2022478034 @default.
• W1973796123 cites W2025364863 @default.
• W1973796123 cites W2025368485 @default.
• W1973796123 cites W2026735889 @default.
• W1973796123 cites W2026899917 @default.
• W1973796123 cites W2029224830 @default.
• W1973796123 cites W2036996443 @default.
• W1973796123 cites W2041676666 @default.
• W1973796123 cites W2043774431 @default.
• W1973796123 cites W2045519476 @default.
• W1973796123 cites W2048062637 @default.
• W1973796123 cites W2049596148 @default.
• W1973796123 cites W2051231096 @default.
• W1973796123 cites W2052626303 @default.
• W1973796123 cites W2054056887 @default.
• W1973796123 cites W2054982182 @default.
• W1973796123 cites W2055050880 @default.
• W1973796123 cites W2057289478 @default.
• W1973796123 cites W2067650067 @default.
• W1973796123 cites W2072310161 @default.
• W1973796123 cites W2073302735 @default.
• W1973796123 cites W2075102280 @default.
• W1973796123 cites W2075599536 @default.
• W1973796123 cites W2086257051 @default.
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• W1973796123 cites W2088038774 @default.
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• W1973796123 cites W2093182897 @default.
• W1973796123 cites W2103908315 @default.
• W1973796123 cites W2109800651 @default.
• W1973796123 cites W2117132446 @default.
• W1973796123 cites W2117632612 @default.
• W1973796123 cites W2119324374 @default.
• W1973796123 cites W2122833172 @default.
• W1973796123 cites W2125995703 @default.
• W1973796123 cites W2132919883 @default.
• W1973796123 cites W2135945506 @default.
• W1973796123 cites W2141160298 @default.
• W1973796123 cites W2142526109 @default.
• W1973796123 cites W2143397316 @default.
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• W1973796123 cites W2149963584 @default.
• W1973796123 cites W2152669400 @default.
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• W1973796123 doi "https://doi.org/10.1002/bies.20382" @default.
• W1973796123 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16547945" @default.
• W1973796123 hasPublicationYear "2006" @default.
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