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- W1973803488 abstract "The relationship was investigated between a viral infectious titer in peripheral blood mononu-clear cells (PBMC) and plasma on the replicative and syncytium-inducing capacity of human immunodeficiency virus type 1 (HIV-1) isolates. The replicative capacity was defined as the minimum time required for p24 antigen to become positive in PBMCs or plasma of HIV-1 infected individuals, cocultured with PBMCs of healthy donors. Syncytium induction was determined by the MT-2 cell assay and defined as the presence of giant multinucleated cells. The replicative capacity of HIV-1 in PBMCs of healthy donors correlated with the infectious viral titer in PBMCs, but not in the plasma of HIV-1 positive patients. Syn-cytia formation in MT-2 cells was not related to the infectious viral titer in PBMCs or plasma of HIV-1 positive patients. These findings suggest that syncytium formation, not replicative capacity, is an intrinsic HIV-1 phenotype. © 1995 Wiley-Liss, Inc." @default.
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- W1973803488 date "1995-01-01" @default.
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- W1973803488 title "Infectious virus titer, replicative and syncytium-inducing capacity of human immunodeficiency virus type 1" @default.
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- W1973803488 doi "https://doi.org/10.1002/jmv.1890450115" @default.
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