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- W1973804928 abstract "The aim of the present article was to examine the effect of PACAP on the release of the SgII-derived peptide EM66 from primary cultures of bovine chromaffin cells. PACAP dose dependently stimulated EM66 release from cultured chromaffin cells. A significant response was observed after 6 h of treatment with PACAP and increased to reach a 3.6-fold stimulation at 72 h. The stimulatory effect of PACAP was mediated through multiple signaling pathways, including calcium influx through L-type channels, PKA, PKC, and MAP-kinase cascades, to regulate EM66 release from chromaffin cells. These data suggest that EM66 may act downstream of the trans-synaptic stimulation of the adrenal medulla by neurocrine factors." @default.
- W1973804928 created "2016-06-24" @default.
- W1973804928 creator A5042399385 @default.
- W1973804928 date "2006-07-01" @default.
- W1973804928 modified "2023-10-02" @default.
- W1973804928 title "PACAP Stimulates the Release of the Secretogranin II-Derived Peptide EM66 from Chromaffin Cells" @default.
- W1973804928 doi "https://doi.org/10.1196/annals.1317.033" @default.
- W1973804928 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16888183" @default.
- W1973804928 hasPublicationYear "2006" @default.
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