FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1973816411> ?p ?o ?g. }

• W1973816411 endingPage "11405" @default.
• W1973816411 startingPage "11400" @default.
• W1973816411 abstract "The early phases of carcinogenesis resemble embryonic development, often involving the reexpression of embryonic mesenchymal genes. The NCI60 panel of human tumor cell lines can genetically be subdivided into two superclusters (SCs) that correspond to CD95 Type I and II cells. SC1 cells are characterized by a mesenchymal and SC2 cells by an epithelial gene signature, suggesting that SC1 cells represent less differentiated, advanced stages of cancer. miRNAs are small 20- to 22-nucleotide-long noncoding RNAs that inhibit gene expression at the posttranscriptional level. By performing miRNA expression analysis on 10 Type I and 10 Type II cells, we have determined that SC1 cells express low and SC2 cells high levels of the miRNA let-7, respectively, suggesting that let-7 is a marker for less advanced cancers. Expression of the let-7 target high-mobility group A2 (HMGA2), an early embryonic gene, but not of classical epithelial or mesenchymal markers such as E-cadherin or vimentin, inversely correlated with let-7 expression in SC1 and SC2 cells. Using ovarian cancer as a model, we demonstrate that expression of let-7 and HMGA2 is a better predictor of prognosis than classical markers such as E-cadherin, vimentin, and Snail. These data identify loss of let-7 expression as a marker for less differentiated cancer." @default.
• W1973816411 created "2016-06-24" @default.
• W1973816411 creator A5016107949 @default.
• W1973816411 creator A5027620152 @default.
• W1973816411 creator A5056699614 @default.
• W1973816411 creator A5057375922 @default.
• W1973816411 creator A5060936292 @default.
• W1973816411 creator A5065115714 @default.
• W1973816411 creator A5067794137 @default.
• W1973816411 creator A5068966386 @default.
• W1973816411 creator A5089821185 @default.
• W1973816411 date "2007-07-03" @default.
• W1973816411 modified "2023-10-14" @default.
• W1973816411 title "Let-7 expression defines two differentiation stages of cancer" @default.
• W1973816411 cites W1513947812 @default.
• W1973816411 cites W1967342065 @default.
• W1973816411 cites W1969015715 @default.
• W1973816411 cites W1973109581 @default.
• W1973816411 cites W1989076816 @default.
• W1973816411 cites W1990868443 @default.
• W1973816411 cites W2006797972 @default.
• W1973816411 cites W2009229545 @default.
• W1973816411 cites W2010215928 @default.
• W1973816411 cites W2016136785 @default.
• W1973816411 cites W2040851084 @default.
• W1973816411 cites W2044702943 @default.
• W1973816411 cites W2055720287 @default.
• W1973816411 cites W2062290101 @default.
• W1973816411 cites W2085776836 @default.
• W1973816411 cites W2096714217 @default.
• W1973816411 cites W2097255042 @default.
• W1973816411 cites W2110666579 @default.
• W1973816411 cites W2116987967 @default.
• W1973816411 cites W2130000923 @default.
• W1973816411 cites W2130355910 @default.
• W1973816411 cites W2130979840 @default.
• W1973816411 cites W2131118100 @default.
• W1973816411 cites W2135314242 @default.
• W1973816411 cites W2140551998 @default.
• W1973816411 cites W2144038313 @default.
• W1973816411 cites W2145021085 @default.
• W1973816411 cites W2149848115 @default.
• W1973816411 cites W2151922790 @default.
• W1973816411 cites W2153693413 @default.
• W1973816411 cites W2159888101 @default.
• W1973816411 cites W2166179294 @default.
• W1973816411 cites W2170647698 @default.
• W1973816411 cites W2259802687 @default.
• W1973816411 cites W2419179378 @default.
• W1973816411 doi "https://doi.org/10.1073/pnas.0704372104" @default.
• W1973816411 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2040910" @default.
• W1973816411 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17600087" @default.
• W1973816411 hasPublicationYear "2007" @default.
• W1973816411 type Work @default.
• W1973816411 sameAs 1973816411 @default.
• W1973816411 citedByCount "417" @default.
• W1973816411 countsByYear W19738164112012 @default.
• W1973816411 countsByYear W19738164112013 @default.
• W1973816411 countsByYear W19738164112014 @default.
• W1973816411 countsByYear W19738164112015 @default.
• W1973816411 countsByYear W19738164112016 @default.
• W1973816411 countsByYear W19738164112017 @default.
• W1973816411 countsByYear W19738164112018 @default.
• W1973816411 countsByYear W19738164112019 @default.
• W1973816411 countsByYear W19738164112020 @default.
• W1973816411 countsByYear W19738164112021 @default.
• W1973816411 countsByYear W19738164112022 @default.
• W1973816411 countsByYear W19738164112023 @default.
• W1973816411 crossrefType "journal-article" @default.
• W1973816411 hasAuthorship W1973816411A5016107949 @default.
• W1973816411 hasAuthorship W1973816411A5027620152 @default.
• W1973816411 hasAuthorship W1973816411A5056699614 @default.
• W1973816411 hasAuthorship W1973816411A5057375922 @default.
• W1973816411 hasAuthorship W1973816411A5060936292 @default.
• W1973816411 hasAuthorship W1973816411A5065115714 @default.
• W1973816411 hasAuthorship W1973816411A5067794137 @default.
• W1973816411 hasAuthorship W1973816411A5068966386 @default.
• W1973816411 hasAuthorship W1973816411A5089821185 @default.
• W1973816411 hasBestOaLocation W19738164111 @default.
• W1973816411 hasConcept C104317684 @default.
• W1973816411 hasConcept C121608353 @default.
• W1973816411 hasConcept C145059251 @default.
• W1973816411 hasConcept C145103041 @default.
• W1973816411 hasConcept C147447768 @default.
• W1973816411 hasConcept C148738053 @default.
• W1973816411 hasConcept C150194340 @default.
• W1973816411 hasConcept C153911025 @default.
• W1973816411 hasConcept C198826908 @default.
• W1973816411 hasConcept C203014093 @default.
• W1973816411 hasConcept C204232928 @default.
• W1973816411 hasConcept C502942594 @default.
• W1973816411 hasConcept C54355233 @default.
• W1973816411 hasConcept C555283112 @default.
• W1973816411 hasConcept C86803240 @default.
• W1973816411 hasConcept C95444343 @default.
• W1973816411 hasConcept C96232424 @default.
• W1973816411 hasConceptScore W1973816411C104317684 @default.
• W1973816411 hasConceptScore W1973816411C121608353 @default.

• next