Matches in SemOpenAlex for { <https://semopenalex.org/work/W1973839401> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W1973839401 endingPage "846" @default.
- W1973839401 startingPage "831" @default.
- W1973839401 abstract "Abstract Twelve mouse hybridomas secreting antibodies to dextran B512, identified by replica immunoadsorption screening of 100,000 immobilized hybridoma clones, were obtained. Among 11 hybridomas of BALB/c origin seven produce IgM and four produce IgA. One hybridoma of C57BL/6 origin synthesizes IgA. A κ light chain is synthesized by each of the 12 hybridomas in addition to the nonspecific κ light chain of the parent myeloma. The heavy chain is shown to associate preferentially with the specific (spleen cell derived) light chain. All hybridoma antibodies were purified from ascites by precipitation with dextran B512, followed by subsequent digestion of the dextran with dextranase. Although all the specific light chains migrate identically in SDS gels under reducing conditions, variations in migration are noticed among the heavy chains. Differences in migration among the IgA monomers and among the IgA polymers are seen on nondenaturing polyacrylamide gels. Densitometer scans of such gels show that more than 50% of the IgA hybridoma antibodies are in polymeric form. Implications of the preferential association of heavy chain with specific light chain, and of the size differences among the heavy chains for the generation of antibody specificity and diversity are discussed." @default.
- W1973839401 created "2016-06-24" @default.
- W1973839401 creator A5003615763 @default.
- W1973839401 creator A5033964608 @default.
- W1973839401 creator A5065494170 @default.
- W1973839401 date "1981-09-01" @default.
- W1973839401 modified "2023-10-16" @default.
- W1973839401 title "Studies on mouse hybridomas secreting IgM or IgA antibodies to α(1→6)-linked dextran" @default.
- W1973839401 cites W1476591324 @default.
- W1973839401 cites W1511965649 @default.
- W1973839401 cites W1540303217 @default.
- W1973839401 cites W1553994434 @default.
- W1973839401 cites W1559504720 @default.
- W1973839401 cites W1560041893 @default.
- W1973839401 cites W1561750927 @default.
- W1973839401 cites W1737898466 @default.
- W1973839401 cites W1754492832 @default.
- W1973839401 cites W1967164602 @default.
- W1973839401 cites W1977833662 @default.
- W1973839401 cites W1980416998 @default.
- W1973839401 cites W1984387553 @default.
- W1973839401 cites W1991873742 @default.
- W1973839401 cites W1995295906 @default.
- W1973839401 cites W1999100206 @default.
- W1973839401 cites W1999311838 @default.
- W1973839401 cites W2007647936 @default.
- W1973839401 cites W2014509927 @default.
- W1973839401 cites W2015699254 @default.
- W1973839401 cites W2030522563 @default.
- W1973839401 cites W2032878873 @default.
- W1973839401 cites W2039531874 @default.
- W1973839401 cites W2040647476 @default.
- W1973839401 cites W2045689642 @default.
- W1973839401 cites W2050583303 @default.
- W1973839401 cites W2056671237 @default.
- W1973839401 cites W2063010252 @default.
- W1973839401 cites W2069725651 @default.
- W1973839401 cites W2069883384 @default.
- W1973839401 cites W2070701326 @default.
- W1973839401 cites W2081334729 @default.
- W1973839401 cites W2084861802 @default.
- W1973839401 cites W2100837269 @default.
- W1973839401 cites W2127552260 @default.
- W1973839401 cites W2141468722 @default.
- W1973839401 cites W2314761595 @default.
- W1973839401 cites W2318036417 @default.
- W1973839401 cites W2340095993 @default.
- W1973839401 cites W2395017276 @default.
- W1973839401 cites W4296939038 @default.
- W1973839401 doi "https://doi.org/10.1016/0161-5890(81)90005-5" @default.
- W1973839401 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6175897" @default.
- W1973839401 hasPublicationYear "1981" @default.
- W1973839401 type Work @default.
- W1973839401 sameAs 1973839401 @default.
- W1973839401 citedByCount "39" @default.
- W1973839401 crossrefType "journal-article" @default.
- W1973839401 hasAuthorship W1973839401A5003615763 @default.
- W1973839401 hasAuthorship W1973839401A5033964608 @default.
- W1973839401 hasAuthorship W1973839401A5065494170 @default.
- W1973839401 hasConcept C159654299 @default.
- W1973839401 hasConcept C185592680 @default.
- W1973839401 hasConcept C203014093 @default.
- W1973839401 hasConcept C2777339698 @default.
- W1973839401 hasConcept C55493867 @default.
- W1973839401 hasConcept C86803240 @default.
- W1973839401 hasConceptScore W1973839401C159654299 @default.
- W1973839401 hasConceptScore W1973839401C185592680 @default.
- W1973839401 hasConceptScore W1973839401C203014093 @default.
- W1973839401 hasConceptScore W1973839401C2777339698 @default.
- W1973839401 hasConceptScore W1973839401C55493867 @default.
- W1973839401 hasConceptScore W1973839401C86803240 @default.
- W1973839401 hasIssue "9" @default.
- W1973839401 hasLocation W19738394011 @default.
- W1973839401 hasLocation W19738394012 @default.
- W1973839401 hasOpenAccess W1973839401 @default.
- W1973839401 hasPrimaryLocation W19738394011 @default.
- W1973839401 hasRelatedWork W1565677340 @default.
- W1973839401 hasRelatedWork W1892461249 @default.
- W1973839401 hasRelatedWork W1995617640 @default.
- W1973839401 hasRelatedWork W2028901469 @default.
- W1973839401 hasRelatedWork W2036939708 @default.
- W1973839401 hasRelatedWork W2102440256 @default.
- W1973839401 hasRelatedWork W2169024102 @default.
- W1973839401 hasRelatedWork W2400126894 @default.
- W1973839401 hasRelatedWork W2403537506 @default.
- W1973839401 hasRelatedWork W4313310570 @default.
- W1973839401 hasVolume "18" @default.
- W1973839401 isParatext "false" @default.
- W1973839401 isRetracted "false" @default.
- W1973839401 magId "1973839401" @default.
- W1973839401 workType "article" @default.